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Antioxidant, Lipid Lowering, and Membrane Stabilization Effect of Sesamol against Doxorubicin-Induced Cardiomyopathy in Experimental Rats
Joint Authors
Chennuru, Anusha
Saleem, Mohamed T. S.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-21
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The present study was designed to evaluate the cardioprotective effect of sesamol against doxorubicin-induced cardiomyopathy in rats.
In this study, the cardioprotective effect of sesamol against doxorubicin induced cardiomyopathy in experimental rats was evaluated at the dosage of 50 mg/kg bw.
Doxorubicin was administered to rats at a total cumulative dose of 15 mg/kg through intraperitoneal route for 2 weeks in six-divided dose on 8th, 10th, 14th, 16th, 18th, and 21st day.
After the last dose administration, the endogenous antioxidants and lipid peroxidation were estimated in heart tissue homogenate.
Cardiac biomarkers such as troponin T, LDH, CK, and AST and lipid profiles such as cholesterol, triglycerides, HDL, LDL, and VLDL were estimated in serum.
Sesamol has cardioprotective activity through normalization of doxorubicin-induced-altered biochemical parameters.
Biochemical study was further supported by histopathological study, which shows that sesamol offered myocardial protection from necrotic damage.
From these findings, it has been concluded that the sesamol has significant cardioprotection against doxorubicin induced cardiomyopathy via amelioration of oxidative stress, lipid lowering, and membrane stabilization effect.
American Psychological Association (APA)
Chennuru, Anusha& Saleem, Mohamed T. S.. 2013. Antioxidant, Lipid Lowering, and Membrane Stabilization Effect of Sesamol against Doxorubicin-Induced Cardiomyopathy in Experimental Rats. BioMed Research International،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1005463
Modern Language Association (MLA)
Chennuru, Anusha& Saleem, Mohamed T. S.. Antioxidant, Lipid Lowering, and Membrane Stabilization Effect of Sesamol against Doxorubicin-Induced Cardiomyopathy in Experimental Rats. BioMed Research International No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1005463
American Medical Association (AMA)
Chennuru, Anusha& Saleem, Mohamed T. S.. Antioxidant, Lipid Lowering, and Membrane Stabilization Effect of Sesamol against Doxorubicin-Induced Cardiomyopathy in Experimental Rats. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1005463
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005463