Radioprotective Effects of Gallic Acid in Mice
Joint Authors
Nair, Gopakumar Gopinathan
Nair, Cherupally Krishnan Krishnan
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-28
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Radioprotecting ability of the natural polyphenol, gallic acid (3,4,5-trihydroxybenzoic acid, GA), was investigated in Swiss albino mice.
Oral administration of GA (100 mg/kg body weight), one hour prior to whole body gamma radiation exposure (2–8 Gy; 6 animals/group), reduced the radiation-induced cellular DNA damage in mouse peripheral blood leukocytes, bone marrow cells, and spleenocytes as revealed by comet assay.
The GA administration also prevented the radiation-induced decrease in the levels of the antioxidant enzyme, glutathione peroxidise (GPx), and nonprotein thiol glutathione (GSH) and inhibited the peroxidation of membrane lipids in these animals.
Exposure of mice to whole body gamma radiation also caused the formation of micronuclei in blood reticulocytes and chromosomal aberrations in bone marrow cells, and the administration of GA resulted in the inhibition of micronucleus formation and chromosomal aberrations.
In irradiated animals, administration of GA elicited an enhancement in the rate of DNA repair process and a significant increase in endogenous spleen colony formation.
The administration of GA also prevented the radiation-induced weight loss and mortality in animals (10 animals/group) exposed to lethal dose (10 Gy) of gamma radiation.
(For every experiment unirradiated animals without GA administration were taken as normal control; specific dose (Gy) irradiated animals without GA administration serve as radiation control; and unirradiated GA treated animals were taken as drug alone control).
American Psychological Association (APA)
Nair, Gopakumar Gopinathan& Nair, Cherupally Krishnan Krishnan. 2013. Radioprotective Effects of Gallic Acid in Mice. BioMed Research International،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1005502
Modern Language Association (MLA)
Nair, Gopakumar Gopinathan& Nair, Cherupally Krishnan Krishnan. Radioprotective Effects of Gallic Acid in Mice. BioMed Research International No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-1005502
American Medical Association (AMA)
Nair, Gopakumar Gopinathan& Nair, Cherupally Krishnan Krishnan. Radioprotective Effects of Gallic Acid in Mice. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1005502
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005502