In Vivo Imaging of Leukocyte Recruitment to the Atheroprone Femoral Artery Reveals Anti-Inflammatory Effects of Rosuvastatin
Joint Authors
Osaka, Mizuko
Hagita, Sumihiko
Yoshida, Masayuki
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
To monitor the anti-inflammatory effect of rosuvastatin in leukocyte endothelial interactions in the atheroprone femoral artery in vivo.
Methods and Results.
Male Apolipoprotein E null mice (ApoE−/− mice, 6 weeks old) were fed a high-fat diet (20% fat, 1.25% cholesterol) with or without the HMG CoA reductase inhibitor rosuvastatin (10 mg/kg/day) for 6 weeks.
Significant leukocyte adhesion was observed in the femoral artery of ApoE−/− mice, but not of wild type mice, in the absence of rosuvastatin.
Interestingly, no obvious plaque formation was observed in the artery at this time point.
The number of adherent leukocytes was dramatically diminished in ApoE−/− mice treated with rosuvastatin.
DHE-associated oxidative stress and the expression of gp91-phox, a component of NADPH oxidase, were induced in ApoE−/− mice and were abolished by rosuvastatin treatment.
Conclusion.
Our data documented leukocyte recruitment prior to lipid accumulation and subsequent inhibition by rosuvastatin.
The underlying mechanism seemed to involve oxidative stress and an anti-inflammatory effect on the endothelium of atheroprone vessels.
American Psychological Association (APA)
Osaka, Mizuko& Hagita, Sumihiko& Yoshida, Masayuki. 2012. In Vivo Imaging of Leukocyte Recruitment to the Atheroprone Femoral Artery Reveals Anti-Inflammatory Effects of Rosuvastatin. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1005525
Modern Language Association (MLA)
Osaka, Mizuko…[et al.]. In Vivo Imaging of Leukocyte Recruitment to the Atheroprone Femoral Artery Reveals Anti-Inflammatory Effects of Rosuvastatin. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1005525
American Medical Association (AMA)
Osaka, Mizuko& Hagita, Sumihiko& Yoshida, Masayuki. In Vivo Imaging of Leukocyte Recruitment to the Atheroprone Femoral Artery Reveals Anti-Inflammatory Effects of Rosuvastatin. BioMed Research International. 2012. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1005525
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005525