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Nonsmall Cell Lung Cancer Therapy: Insight into Multitargeted Small-Molecule Growth Factor Receptor Inhibitors
Joint Authors
Roy, Mridul
Luo, Yu-Hao
Ye, Mao
Liu, Jing
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
To date, lung cancer is the leading cause of cancer-related death worldwide, among which nonsmall cell lung cancer (NSCLC) comprises about 85%.
Taking into account the side effects of surgery, radiation, platinum-based doublet chemotherapy, and the growth self-sufficiency characteristic of cancer cells, drugs have been discovered toward growth factor receptor (GFR) to treat NSCLC.
As expected, these drugs provide a greater benefit.
To increase the efficacy of such growth factor receptor tyrosine kinase inhibitors (RTKIs), coinhibition of GFR signaling pathways and combination of inhibitors along with radiation or chemotherapy have drew intense insight.
Although clinical trials about single-agent RTKIs or their combination strategies suggest their increase potency against cancer, they are not beyond adverse effects, and sometimes the effects are more deadly than chemotherapy.
Nevertheless the hope for RTKIs may be proved true by further researches and digging deep into cancer therapeutics.
American Psychological Association (APA)
Roy, Mridul& Luo, Yu-Hao& Ye, Mao& Liu, Jing. 2013. Nonsmall Cell Lung Cancer Therapy: Insight into Multitargeted Small-Molecule Growth Factor Receptor Inhibitors. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1005532
Modern Language Association (MLA)
Roy, Mridul…[et al.]. Nonsmall Cell Lung Cancer Therapy: Insight into Multitargeted Small-Molecule Growth Factor Receptor Inhibitors. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1005532
American Medical Association (AMA)
Roy, Mridul& Luo, Yu-Hao& Ye, Mao& Liu, Jing. Nonsmall Cell Lung Cancer Therapy: Insight into Multitargeted Small-Molecule Growth Factor Receptor Inhibitors. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1005532
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005532