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The Mode of Inheritance of Scheuermann’s Disease
Joint Authors
Zaidman, A. M.
Zaidman, M. N.
Strokova, E. L.
Korel, A. V.
Kalashnikova, E. V.
Rusova, T. V.
Mikhailovsky, M. V.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The mode of Scheuermann’s disease inheritance and its phenotypic traits in probands and their relatives were studied in 90 pedigrees (90 probands and 385 relatives).
The disorder was identified as a genetically related pathology inherited by autosomal dominant type, controlled by a mutant major gene, as a kyphotic deformity without signs of vertebral bodies’ anomaly and torsion.
Morphological and biochemical studies showed disturbance in the structure of vertebral growth plate anterior aspects at the level of deformity, defects in proliferation and differentiation of chondrocytes, and change in proteoglycan spectrum in cells and matrix.
Twelve candidate genes were studied in chondrocytes isolated from vertebral growth plates of patients with Scheuermann’s disease.
The study results included disorder in the IHH gene expression and preservation of the expression of PAX1, two aggrecan isoforms, link protein, types I and II collagen, lumican, versican, growth hormone and growth factor receptor genes, and proliferation gene.
Preservation of the SOX9 gene (transcription gene) probably indicates posttranscriptional genetic disorders.
The study is under way.
American Psychological Association (APA)
Zaidman, A. M.& Zaidman, M. N.& Strokova, E. L.& Korel, A. V.& Kalashnikova, E. V.& Rusova, T. V.…[et al.]. 2013. The Mode of Inheritance of Scheuermann’s Disease. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1005548
Modern Language Association (MLA)
Zaidman, A. M.…[et al.]. The Mode of Inheritance of Scheuermann’s Disease. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1005548
American Medical Association (AMA)
Zaidman, A. M.& Zaidman, M. N.& Strokova, E. L.& Korel, A. V.& Kalashnikova, E. V.& Rusova, T. V.…[et al.]. The Mode of Inheritance of Scheuermann’s Disease. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1005548
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005548