Disease Modifying Therapies for Alzheimer's Disease Targeting Aβ Oligomers: Implications for Therapeutic Mechanisms
Joint Authors
Shoji, Mikio
Matsubara, Etsuro
Takamura, Ayumi
Okamoto, Yasuhide
Oono, Hideto
Nakata, Takashi
Wakasaya, Yasuhito
Kawarabayashi, Takeshi
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Several lines of evidence indicate that amyloid β (Aβ), particularly Aβ oligomers (AβOs), plays a causative role in Alzheimer's disease.
However, the mechanisms underlying the action of an anti-AβO antibody to clarify the toxic action of AβOs remain elusive.
Here, we showed that the anti-AβO antibody (monoclonal 72D9) can modify the Aβ aggregation pathway.
We also found that 72D9 directly sequesters both extracellular and intraneuronal AβOs in a nontoxic state.
Thus, therapeutic intervention targeting AβOs is a promising strategy for neuronal protection in Alzheimer's disease.
American Psychological Association (APA)
Matsubara, Etsuro& Takamura, Ayumi& Okamoto, Yasuhide& Oono, Hideto& Nakata, Takashi& Wakasaya, Yasuhito…[et al.]. 2013. Disease Modifying Therapies for Alzheimer's Disease Targeting Aβ Oligomers: Implications for Therapeutic Mechanisms. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1005574
Modern Language Association (MLA)
Matsubara, Etsuro…[et al.]. Disease Modifying Therapies for Alzheimer's Disease Targeting Aβ Oligomers: Implications for Therapeutic Mechanisms. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1005574
American Medical Association (AMA)
Matsubara, Etsuro& Takamura, Ayumi& Okamoto, Yasuhide& Oono, Hideto& Nakata, Takashi& Wakasaya, Yasuhito…[et al.]. Disease Modifying Therapies for Alzheimer's Disease Targeting Aβ Oligomers: Implications for Therapeutic Mechanisms. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1005574
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005574