A Glimpse of the Pathogenetic Mechanisms of Wntβ-Catenin Signaling in Diabetic Nephropathy
Joint Authors
Xiao, Li
Wang, Ming
Yang, Shikun
Liu, Fuyou
Sun, Lin
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The Wnt family of proteins belongs to a group of secreted lipid-modified glycoproteins with highly conserved cysteine residues.
Prior results indicate that Wnt/β-catenin signaling plays a prominent role in cell differentiation, adhesion, survival, and apoptosis and is involved in organ development, tumorigenesis, and tissue fibrosis, among other functions.
Accumulating evidence has suggested that Wnt/β-catenin exhibits a pivotal function in the progression of diabetic nephropathy (DN).
In this review, we focused on discussing the dual role of Wnt/β-catenin in apoptosis and epithelial mesenchymal transition (EMT) formation of mesangial cells.
Moreover, we also elucidated the effect of Wnt/β-catenin in podocyte dysfunction, tubular EMT formation, and renal fibrosis under DN conditions.
In addition, the molecular mechanisms involved in this process are introduced.
This information provides a novel molecular target of Wnt/β-catenin for the protection of kidney damage and in delay of the progression of DN.
American Psychological Association (APA)
Xiao, Li& Wang, Ming& Yang, Shikun& Liu, Fuyou& Sun, Lin. 2013. A Glimpse of the Pathogenetic Mechanisms of Wntβ-Catenin Signaling in Diabetic Nephropathy. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1005580
Modern Language Association (MLA)
Xiao, Li…[et al.]. A Glimpse of the Pathogenetic Mechanisms of Wntβ-Catenin Signaling in Diabetic Nephropathy. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1005580
American Medical Association (AMA)
Xiao, Li& Wang, Ming& Yang, Shikun& Liu, Fuyou& Sun, Lin. A Glimpse of the Pathogenetic Mechanisms of Wntβ-Catenin Signaling in Diabetic Nephropathy. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1005580
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005580