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Comparative Analysis of Context-Dependent Mutagenesis Using Human and Mouse Models
Joint Authors
Alexeevski, Andrey V.
Panchin, Alexander Y.
Panchin, Yuri V.
Medvedeva, Sofya A.
Spirin, Sergey A.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-22
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Substitution rates strongly depend on their nucleotide context.
One of the most studied examples is the excess of C > T mutations in the CG context in various groups of organisms, including vertebrates.
Studies on the molecular mechanisms underlying this mutation regularity have provided insights into evolution, mutagenesis, and cancer development.
Recently several other hypermutable motifs were identified in the human genome.
There is an increased frequency of T > C mutations in the second position of the words ATTG and ATAG and an increased frequency of A > C mutations in the first position of the word ACAA.
For a better understanding of evolution, it is of interest whether these mutation regularities are human specific or present in other vertebrates, as their presence might affect the validity of currently used substitution models and molecular clocks.
A comprehensive analysis of mutagenesis in 4 bp mutation contexts requires a vast amount of mutation data.
Such data may be derived from the comparisons of individual genomes or from single nucleotide polymorphism (SNP) databases.
Using this approach, we performed a systematical comparison of mutation regularities within 2–4 bp contexts in Mus musculus and Homo sapiens and uncovered that even closely related organisms may have notable differences in context-dependent mutation regularities.
American Psychological Association (APA)
Medvedeva, Sofya A.& Panchin, Alexander Y.& Alexeevski, Andrey V.& Spirin, Sergey A.& Panchin, Yuri V.. 2013. Comparative Analysis of Context-Dependent Mutagenesis Using Human and Mouse Models. BioMed Research International،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1005581
Modern Language Association (MLA)
Medvedeva, Sofya A.…[et al.]. Comparative Analysis of Context-Dependent Mutagenesis Using Human and Mouse Models. BioMed Research International No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1005581
American Medical Association (AMA)
Medvedeva, Sofya A.& Panchin, Alexander Y.& Alexeevski, Andrey V.& Spirin, Sergey A.& Panchin, Yuri V.. Comparative Analysis of Context-Dependent Mutagenesis Using Human and Mouse Models. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1005581
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005581