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Association between Rash and a Positive Drug Response Associated with Vinorelbine in a Patient with Primary Peritoneal Carcinoma
Joint Authors
Saif, Muhammad Wasif
Mohammad, Mustafa M.
Syrigos, Kostas N.
Source
Case Reports in Dermatological Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-01
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Vinorelbine (Navelbine, VRL) is commonly used for platinum-resistant ovarian cancer and has been shown to be effective in patients with recurrent primary peritoneal carcinoma.
Of VRL’s major side effects, skin rash is uncommon, and, if it does occur, it is usually localized to site of injection.
In this case report, a 71-year-old Hispanic female with primary peritoneal carcinoma received single agent VRL as fourth-line regimen, which she tolerated very well except for a skin rash related to VRL.
The rash continued to progress throughout 6 cycles of VRL, and follow-up CT/PET scan demonstrated complete metabolic and radiological responses.
We, therefore, believe that this rash was linked to VRL administration and correlated with response to therapy.
Rash has been recognized as a useful surrogate marker with targeted agents such as cetuximab and erlotinib; to the best of our knowledge, this case report describes the first patient with a possible drug rash and its association with a positive outcome.
This case report incites interest in further investigation of similar cases to support this observation, since there is a lack of reports of skin rash with VRL therapy.
American Psychological Association (APA)
Mohammad, Mustafa M.& Syrigos, Kostas N.& Saif, Muhammad Wasif. 2013. Association between Rash and a Positive Drug Response Associated with Vinorelbine in a Patient with Primary Peritoneal Carcinoma. Case Reports in Dermatological Medicine،Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-1005612
Modern Language Association (MLA)
Mohammad, Mustafa M.…[et al.]. Association between Rash and a Positive Drug Response Associated with Vinorelbine in a Patient with Primary Peritoneal Carcinoma. Case Reports in Dermatological Medicine No. 2013 (2013), pp.1-3.
https://search.emarefa.net/detail/BIM-1005612
American Medical Association (AMA)
Mohammad, Mustafa M.& Syrigos, Kostas N.& Saif, Muhammad Wasif. Association between Rash and a Positive Drug Response Associated with Vinorelbine in a Patient with Primary Peritoneal Carcinoma. Case Reports in Dermatological Medicine. 2013. Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-1005612
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005612