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Rapidly Developing Toxic Epidermal Necrolysis
Joint Authors
Nielsen, Jonas
Poulsen, Viktoria Oline Barrios
Poulsen, Troels Dirch
Source
Case Reports in Emergency Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-27
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Severe cutaneous reactions with potentially fatal outcomes can have many different causes.
The Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare.
They are characterized by a low incidence but high mortality, and drugs are most commonly implicated.
Urgent active therapy is required.
Prompt recognition and withdrawal of suspect drug and rapid intervention can result in favourable outcome.
No further international guidelines for treatment exist, and much of the treatment relies on old or experimental concepts with no scientific evidence.
We report on a 54-year-old man experiencing rapidly developing drug-induced severe TEN and presented multiorgan failure involving the respiratory and circulatory system, coagulopathy, and renal insufficiency.
Detachment counted 30% of total body surface area (TBSA).
SCORTEN = 5, indicating a mortality rate >90%.
The patient was sedated and mechanically ventilated, supported with fluids and inotropes to maintain a stable circulation.
Component therapy was guided by thromboelastography (TEG).
The patient received plasmapheresis, and shock reversal treatment was initiated.
He was transferred to a specialized intensive care burn unit within 24 hours from admittance.
The initial care was continued, and hemodialysis was started.
Pulmonary, circulatory, and renal sequelae resolved with intensive care, and re-epithelialization progressed slowly.
The patient was discharged home on hospital day 19.
American Psychological Association (APA)
Poulsen, Viktoria Oline Barrios& Nielsen, Jonas& Poulsen, Troels Dirch. 2013. Rapidly Developing Toxic Epidermal Necrolysis. Case Reports in Emergency Medicine،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-1005670
Modern Language Association (MLA)
Poulsen, Viktoria Oline Barrios…[et al.]. Rapidly Developing Toxic Epidermal Necrolysis. Case Reports in Emergency Medicine No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-1005670
American Medical Association (AMA)
Poulsen, Viktoria Oline Barrios& Nielsen, Jonas& Poulsen, Troels Dirch. Rapidly Developing Toxic Epidermal Necrolysis. Case Reports in Emergency Medicine. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-1005670
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005670