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Spruelike Enteropathy Associated with Olmesartan: An Unusual Case of Severe Diarrhea
Joint Authors
Dreifuss, Stephanie E.
Davison, Jon M.
Tomizawa, Yutaka
Sohnen, Adam E.
Farber, Nicholas J.
Source
Case Reports in Gastrointestinal Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-13
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
A 64-year-old male with a history of hypertension presented with worsening diarrhea and 25-pound weight loss over the preceding three months.
Prior screening colonoscopy was unremarkable, and the patient failed conservative management.
On presentation, the patient had orthostatic hypotension associated with prerenal azotemia for which olmesartan (40 mg/day) was held.
Initial workup for chronic diarrhea was essentially unremarkable.
Then, EGD was performed with small bowel biopsy, which showed a moderate villous blunting and an intraepithelial lymphocyte infiltration.
Celiac disease was excluded by negative conventional serology tests and the absence of clinical response to a gluten-free diet.
In the interim, diarrhea became resolving without any other interventions, and clinical response was achieved even with gluten-containing diet.
Two months later, he achieved a complete resolution of diarrhea and regained 20-pound weight.
Spruelike enteropathy is a clinical entity manifested by chronic diarrhea and intestinal villous atrophy.
Spruelike enteropathy associated with olmesartan as a cause of drug-induced diarrhea is rare, and it has been reported only in a case series to date.
This case highlighted the importance for clinicians to maintain a high index of suspicion for olmesartan as a precipitant of spruelike enteropathy.
American Psychological Association (APA)
Dreifuss, Stephanie E.& Tomizawa, Yutaka& Farber, Nicholas J.& Davison, Jon M.& Sohnen, Adam E.. 2013. Spruelike Enteropathy Associated with Olmesartan: An Unusual Case of Severe Diarrhea. Case Reports in Gastrointestinal Medicine،Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-1005698
Modern Language Association (MLA)
Dreifuss, Stephanie E.…[et al.]. Spruelike Enteropathy Associated with Olmesartan: An Unusual Case of Severe Diarrhea. Case Reports in Gastrointestinal Medicine No. 2013 (2013), pp.1-3.
https://search.emarefa.net/detail/BIM-1005698
American Medical Association (AMA)
Dreifuss, Stephanie E.& Tomizawa, Yutaka& Farber, Nicholas J.& Davison, Jon M.& Sohnen, Adam E.. Spruelike Enteropathy Associated with Olmesartan: An Unusual Case of Severe Diarrhea. Case Reports in Gastrointestinal Medicine. 2013. Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-1005698
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005698