Anorectal Gastrointestinal Stromal Tumor: A Case Report and Literature Review
Joint Authors
Chandrakant, Singh
Varghese, Vineet
Chauhan, Pushkar
Ballani, Amit
Dhuria, Ankur Subhash
Singhal, Anu
Arora, Pankaj K.
Singhal, Sanjeev
Malik, Pawan
Panwar, Vishnu
Tiwari, Bishwanath
Tugnait, Rahul
Bharali, Mriganka Deuri
Source
Case Reports in Gastrointestinal Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-25
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Gastrointestinal stromal tumors or “GIST” are mesenchymal neoplasms expressing KIT(CD117) tyrosine kinase and showing the presence of activating mutations in KIT or PDGFRα (platelet-derived growth factor alpha).
GIST of anal canal is an extremely rare tumor, accounting for only 3% of all anorectal mesenchymal tumors and 0.1–0.4% of all GIST.
GIST with large tumor size and high mitotic activity are highly malignant, but the biological behavior of anorectal GIST is less clear.
Abdominoperineal resection (APR) or conservative surgery is the best treatment option.
Imatinib mesylate, a tyrosine kinase inhibitor, has shown promising results in its management.
We present a case of anorectal GIST diagnosed by computed tomography (CT) scan, magnetic resonance imaging (MRI), and colonoscopy with biopsy.
The patient underwent abdominoperineal resection (APR) and was confirmed on histopathology to have anal canal GIST with tumor size more than 5 cm in maximum dimension and mitotic figures more than 5/50 high power field (HPF).
The CD117—immunoreactive score—was 3+ in spindled cells.
Therefore the patient was put on adjuvant imatinib mesylate 400 mg daily.
American Psychological Association (APA)
Singhal, Sanjeev& Singhal, Anu& Tugnait, Rahul& Varghese, Vineet& Tiwari, Bishwanath& Arora, Pankaj K.…[et al.]. 2013. Anorectal Gastrointestinal Stromal Tumor: A Case Report and Literature Review. Case Reports in Gastrointestinal Medicine،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-1005723
Modern Language Association (MLA)
Singhal, Sanjeev…[et al.]. Anorectal Gastrointestinal Stromal Tumor: A Case Report and Literature Review. Case Reports in Gastrointestinal Medicine No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-1005723
American Medical Association (AMA)
Singhal, Sanjeev& Singhal, Anu& Tugnait, Rahul& Varghese, Vineet& Tiwari, Bishwanath& Arora, Pankaj K.…[et al.]. Anorectal Gastrointestinal Stromal Tumor: A Case Report and Literature Review. Case Reports in Gastrointestinal Medicine. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-1005723
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005723