Association of IL-4-590 C>T and IL-13-1112 C>T Gene Polymorphisms with the Susceptibility to Type 2 Diabetes Mellitus
Joint Authors
Alsaid, Afaf
El-Missiry, Mohammed
Hatata, El-Sayed
Tarabay, Mohammad
Settin, Ahmad
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-09
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The goal of the study is to investigate the association of IL-4-590 and IL-13-1112 genetic polymorphisms with type 2 diabetes mellitus (T2DM) in Egyptian patients.
Subjects and Methods.
The study included 135 cases with T2DM and 75 healthy unrelated age-matched controls from the same locality of Egypt.
DNA was extracted and processed by the ARMS-PCR technique for characterization of genetic variants of IL-4-590 C>T and IL-13-1112 C>T polymorphisms.
Results.
Egyptian cases with T2DM showed a lower frequency of the IL-4-590 CC homozygous genotype compared to controls (10.4% versus 43.48%) with a higher CT heterozygous genotype (85.2% versus 47.8%).
Similarly, cases showed a lower frequency of the IL-13-1112 CC genotype (20.7% versus 56.8%) with a higher frequency of the heterozygous IL-13-1112 CT genotype (76.3% versus 41.3%).
Both polymorphisms showed significantly positive associations with T2DM in the dominant, codominant, and overdominant models of inheritance.
On the other hand, comparing genotypes of subgroups related to gender, positive family history, and positive consanguinity showed a nonsignificant difference (P>0.05).
Conclusion.
Heterozygous genotypes (IL-4-590 CT and IL-13-1112 CT) could be considered as risk factors, while the homozygous wild types (-590 CC and -1112 CC) might be considered protective to T2DM.
American Psychological Association (APA)
Alsaid, Afaf& El-Missiry, Mohammed& Hatata, El-Sayed& Tarabay, Mohammad& Settin, Ahmad. 2013. Association of IL-4-590 C>T and IL-13-1112 C>T Gene Polymorphisms with the Susceptibility to Type 2 Diabetes Mellitus. Disease Markers،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1005788
Modern Language Association (MLA)
Alsaid, Afaf…[et al.]. Association of IL-4-590 C>T and IL-13-1112 C>T Gene Polymorphisms with the Susceptibility to Type 2 Diabetes Mellitus. Disease Markers No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1005788
American Medical Association (AMA)
Alsaid, Afaf& El-Missiry, Mohammed& Hatata, El-Sayed& Tarabay, Mohammad& Settin, Ahmad. Association of IL-4-590 C>T and IL-13-1112 C>T Gene Polymorphisms with the Susceptibility to Type 2 Diabetes Mellitus. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1005788
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005788