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Positive ALDH1A3 and Negative GPX3 Expressions Are Biomarkers for Poor Prognosis of Gallbladder Cancer
Joint Authors
Yang, Zhu-lin
Yang, Leping
Zou, Qiong
Yuan, Yuan
Li, Jinghe
Liang, Lufeng
Zeng, Guixiang
Chen, Senlin
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Gallbladder cancers (GBCs) are highly aggressive cancers with high mortality.
However, biological markers for the progression and prognosis of GBC are currently unavailable in the clinic.
Objective.
To identify biomarkers for predicting GBC metastasis and prognosis.
Methods.
We examined ALDH1A3 and GPX3 expressions in 46 squamous cell/adenosquamous carcinomas (SC/ASC) and 80 adenocarcinomas (AC) by using immunohistochemistry.
Results.
Positive ALDH1A3 and negative GPX3 expressions were significantly associated with lymph node metastasis and invasion of SC/ASCs and ACs.
Univariate Kaplan-Meier analysis showed that either positive ALDH1A3 (P<0.001) or negative GPX3 (P<0.001) expression significantly correlated with decreased overall survival in both SC/ASC and AC patients.
Multivariate Cox regression analysis showed that positive ALDH1A3 expression or negative GPX3 expression was an independent poor-prognostic predictor in both SC/ASC and AC patients.
Conclusions.
Our study suggested that positive ALDH1A3 and negative GPX3 expressions are closely associated with clinical pathological behaviors and poor prognosis of gallbladder cancer.
American Psychological Association (APA)
Yang, Zhu-lin& Yang, Leping& Zou, Qiong& Yuan, Yuan& Li, Jinghe& Liang, Lufeng…[et al.]. 2013. Positive ALDH1A3 and Negative GPX3 Expressions Are Biomarkers for Poor Prognosis of Gallbladder Cancer. Disease Markers،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1005797
Modern Language Association (MLA)
Yang, Zhu-lin…[et al.]. Positive ALDH1A3 and Negative GPX3 Expressions Are Biomarkers for Poor Prognosis of Gallbladder Cancer. Disease Markers No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1005797
American Medical Association (AMA)
Yang, Zhu-lin& Yang, Leping& Zou, Qiong& Yuan, Yuan& Li, Jinghe& Liang, Lufeng…[et al.]. Positive ALDH1A3 and Negative GPX3 Expressions Are Biomarkers for Poor Prognosis of Gallbladder Cancer. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1005797
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005797