Circulating Autoantibodies to LGALS3BP: A Novel Biomarker for Cancer
Joint Authors
Grassadonia, Antonino
Tinari, Nicola
Natoli, Clara
Yahalom, Galit
Iacobelli, Stefano
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
Circulating autoantibodies have been extensively investigated as possible markers for early diagnosis of cancer.
The present study was carried out to investigate whether anti-LGALS3BP IgG autoantibodies could be classified as a biomarker for malignant tumors.
Methods.
An in-house developed enzyme-linked immunosorbent assay was used to detect autoantibodies to LGALS3BP in sera from 71 patients with various types of cancers and 54 healthy subjects matched by age and gender.
Results.
Patients with cancer have significant higher circulating levels of anti-LGALS3BP antibodies as compared to control subjects (P<0.001).
The test has a sensitivity of 33% and a specificity of 98%.
Conclusions.
Anti-LGALS3BP IgG autoantibodies are a promising biomarker for malignant tumors and could play a role in the development of a multimarker assay for the early detection of cancer.
American Psychological Association (APA)
Grassadonia, Antonino& Tinari, Nicola& Natoli, Clara& Yahalom, Galit& Iacobelli, Stefano. 2013. Circulating Autoantibodies to LGALS3BP: A Novel Biomarker for Cancer. Disease Markers،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1005798
Modern Language Association (MLA)
Grassadonia, Antonino…[et al.]. Circulating Autoantibodies to LGALS3BP: A Novel Biomarker for Cancer. Disease Markers No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1005798
American Medical Association (AMA)
Grassadonia, Antonino& Tinari, Nicola& Natoli, Clara& Yahalom, Galit& Iacobelli, Stefano. Circulating Autoantibodies to LGALS3BP: A Novel Biomarker for Cancer. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1005798
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005798