Diagnostic Significance of Serum Eotaxin-1 Level in Gastric Cancer Patients
Joint Authors
Koç, Ümit
Çetinkaya, Erdinç
Bostanci, Erdal B.
Kemık, Ahu S.
Tez, Mesut
Gömceli, İsmail
Akoğlu, Musa
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-25
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Gastric cancer is the second cause of cancer-related deaths worldwide.
Delayed diagnosis leads to high mortality rates.
Eotaxin-1 was originally discovered as an eosinophil-selective chemoattractant and may play a role in a number of chronic inflammatory diseases, cancer, and other gastrointestinal disorders.
The aim of this study was to analyse diagnostic and prognostic significance of serum eotaxin-1 (s-eotaxin-1) levels in gastric cancer.
Methods.
Sixty gastric cancer patients and 69 healthy subjects were included into the study.
S-eotaxin-1 levels were compared with clinicopathological features and outcomes in gastric cancer.
Results.
Serum levels of eotaxin-1 in gastric cancer patients were significantly higher than controls (74.51±16.65 pg/mL versus 16.79±5.52 pg/mL, respectively (P<0.001)).
The s-eotaxin-1 levels did not differ significantly with histopathological grade, tumor-node-metastasis (TNM) stage, tumor localization, lymph node metastases, positive lymph node ratio, size, perineural and perivascular invasion.
So there is no relationship found between s-eotaxin-1 level and prognosis.
Conclusion.
S-eotaxin-1 levels may be used as an easily available biomarker for gastric cancer risk and may alert physicians for early diagnosis.
Due to the limited number of patients included in this study, larger cohort studies are warranted to validate the diagnostic value of s-eotaxin-1 level in gastric cancer.
American Psychological Association (APA)
Koç, Ümit& Çetinkaya, Erdinç& Bostanci, Erdal B.& Kemık, Ahu S.& Tez, Mesut& Gömceli, İsmail…[et al.]. 2013. Diagnostic Significance of Serum Eotaxin-1 Level in Gastric Cancer Patients. Disease Markers،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1005806
Modern Language Association (MLA)
Koç, Ümit…[et al.]. Diagnostic Significance of Serum Eotaxin-1 Level in Gastric Cancer Patients. Disease Markers No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1005806
American Medical Association (AMA)
Koç, Ümit& Çetinkaya, Erdinç& Bostanci, Erdal B.& Kemık, Ahu S.& Tez, Mesut& Gömceli, İsmail…[et al.]. Diagnostic Significance of Serum Eotaxin-1 Level in Gastric Cancer Patients. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1005806
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005806