Mycobacterial Dormancy Regulon Protein Rv2623 as a Novel Biomarker for the Diagnosis of Latent and Active Tuberculous Meningitis
Joint Authors
Jain, Ruchika K.
Nayak, Amit R.
Husain, Aliabbas A.
Panchbhai, Milind S.
Chandak, Nitin
Purohit, Hemant J.
Taori, Girdhar M.
Daginawala, Hatim F.
Kashyap, Rajpal S.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The present study was designed to investigate Rv2623 antigen, a major dormancy regulon protein of Mycobacterium tuberculosis (MTB) in CSF of suspected latent and active tuberculous meningitis (TBM) patients.
A total of 100 CSF samples from TBM (n=31), suspected latent TBM (n=22), and suitable noninfectious control subjects (n=47) were collected and evaluated for Rv2623 antigen level using ELISA protocol.
A significantly high (P<0.05) mean absorbance was observed in samples of suspected latent TBM and active TBM patients as compared to non-TBM control patients.
However, no significant difference in Rv2623 level was observed between suspected latent TBM and TBM patients.
Our preliminary findings suggest that Rv2623 may be useful as a potential biomarker for the diagnosis of the latent as well as active TBM infection.
Futher evaluation of this biomarker in large number of samples is therefore needed to confirm the result.
American Psychological Association (APA)
Jain, Ruchika K.& Nayak, Amit R.& Husain, Aliabbas A.& Panchbhai, Milind S.& Chandak, Nitin& Purohit, Hemant J.…[et al.]. 2013. Mycobacterial Dormancy Regulon Protein Rv2623 as a Novel Biomarker for the Diagnosis of Latent and Active Tuberculous Meningitis. Disease Markers،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1005814
Modern Language Association (MLA)
Jain, Ruchika K.…[et al.]. Mycobacterial Dormancy Regulon Protein Rv2623 as a Novel Biomarker for the Diagnosis of Latent and Active Tuberculous Meningitis. Disease Markers No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1005814
American Medical Association (AMA)
Jain, Ruchika K.& Nayak, Amit R.& Husain, Aliabbas A.& Panchbhai, Milind S.& Chandak, Nitin& Purohit, Hemant J.…[et al.]. Mycobacterial Dormancy Regulon Protein Rv2623 as a Novel Biomarker for the Diagnosis of Latent and Active Tuberculous Meningitis. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1005814
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005814
