Sex-Specific Genomic Biomarkers for Individualized Treatment of Life-Threatening Diseases

Abstract EN

Numerous studies have demonstrated sex differences in drug reactions to the same drug treatment, steering away from the traditional view of one-size-fits-all medicine.

A premise of this study is that the sex of a patient influences difference in disease characteristics and risk factors.

In this study, we intend to exploit and to obtain better sex-specific biomarkers from gene-expression data.

We propose a procedure to isolate a set of important genes as sex-specific genomic biomarkers, which may enable more effective patient treatment.

A set of sex-specific genes is obtained by a variable importance ranking using a combination of cross-validation methods.

The proposed procedure is applied to three gene-expression datasets.