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Regulation of Breast Cancer and Bone Metastasis by MicroRNAs
Joint Authors
Vimalraj, S.
Miranda, P. J.
Ramyakrishna, B.
Selvamurugan, N.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-26
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Breast cancer progression including bone metastasis is a complex process involving numerous changes in gene expression and function.
MicroRNAs (miRNAs) are small endogenous noncoding RNAs that regulate gene expression by targeting protein-coding mRNAs posttranscriptionally, often affecting a number of gene targets simultaneously.
Alteration in expression of miRNAs is common in human breast cancer, possessing with either oncogenic or tumor suppressive activity.
The expression and the functional role of several miRNAs (miR-206, miR-31, miR-27a/b, miR-21, miR-92a, miR-205, miR-125a/b, miR-10b, miR-155, miR-146a/b, miR-335, miR-204, miR-211, miR-7, miR-22, miR-126, and miR-17) in breast cancer has been identified.
In this review we summarize the experimentally validated targets of up- and downregulated miRNAs and their regulation in breast cancer and bone metastasis for diagnostic and therapeutic purposes.
American Psychological Association (APA)
Vimalraj, S.& Miranda, P. J.& Ramyakrishna, B.& Selvamurugan, N.. 2013. Regulation of Breast Cancer and Bone Metastasis by MicroRNAs. Disease Markers،Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-1005825
Modern Language Association (MLA)
Vimalraj, S.…[et al.]. Regulation of Breast Cancer and Bone Metastasis by MicroRNAs. Disease Markers No. 2013 (2013), pp.1-19.
https://search.emarefa.net/detail/BIM-1005825
American Medical Association (AMA)
Vimalraj, S.& Miranda, P. J.& Ramyakrishna, B.& Selvamurugan, N.. Regulation of Breast Cancer and Bone Metastasis by MicroRNAs. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-1005825
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005825