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Mast Cells as a Potential Prognostic Marker in Prostate Cancer
Joint Authors
Taverna, Gianluigi
Grizzi, Fabio
Štifter, Sanja
Hurle, Rodolfo
Seveso, Mauro
Colombo, Piergiuseppe
Giusti, Guido
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Despite years of intensive investigation that has been made in understanding prostate cancer, it remains one of the major men’s health issues and the leading cause of death worldwide.
It is now ascertained that prostate cancer emerges from multiple spontaneous and/or inherited alterations that induce changes in expression patterns of genes and proteins that function in complex networks controlling critical cellular events.
It is now accepted that several innate and adaptive immune cells, including T- and B-lymphocytes, macrophages, natural killer cells, dendritic cells, neutrophils, eosinophils, and mast cells (MCs), infiltrate the prostate cancer.
All of these cells are irregularly scattered within the tumor and loaded with an assorted array of cytokines, chemokines, and inflammatory and cytotoxic mediators.
This complex framework reflects the diversity in tumor biology and tumor-host interactions.
MCs are well-established effector cells in Immunoglobulin-E (Ig-E) associated immune responses and potent effector cells of the innate immune system; however, their clinical significance in prostate cancer is still debated.
Here, these controversies are summarized, focusing on the implications of these findings in understanding the roles of MCs in primary prostate cancer.
American Psychological Association (APA)
Taverna, Gianluigi& Giusti, Guido& Seveso, Mauro& Hurle, Rodolfo& Colombo, Piergiuseppe& Štifter, Sanja…[et al.]. 2013. Mast Cells as a Potential Prognostic Marker in Prostate Cancer. Disease Markers،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1005828
Modern Language Association (MLA)
Taverna, Gianluigi…[et al.]. Mast Cells as a Potential Prognostic Marker in Prostate Cancer. Disease Markers No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1005828
American Medical Association (AMA)
Taverna, Gianluigi& Giusti, Guido& Seveso, Mauro& Hurle, Rodolfo& Colombo, Piergiuseppe& Štifter, Sanja…[et al.]. Mast Cells as a Potential Prognostic Marker in Prostate Cancer. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1005828
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005828