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Expression Profile of IL-35 mRNA in Gingiva of Chronic Periodontitis and Aggressive Periodontitis Patients: A Semiquantitative RT-PCR Study
Joint Authors
Kalburgi, Nagaraj B.
Muley, Akshay
Shivaprasad, B. M.
Koregol, Arati C.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-27
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Proinflammatory and anti-inflammatory cytokines play a key role in the pathogenesis of periodontal diseases.
Secretion of bioactive IL-35 has been described by T regulatory cells (Tregs) and is required for their maximal suppressive activity.
Tregs are involved in the modulation of local immune response in chronic periodontitis patients.
Objective.
Hence, the present study was aimed to investigate the expression of IL-35 mRNA in chronic periodontitis and aggressive periodontitis patients.
Materials and Methods.
The present study was carried out in 60 subjects, which included 20 chronic periodontitis patients, 20 aggressive periodontitis patients, and 20 periodontally healthy controls.
IL-35 mRNA expression in gingival tissue samples of all subjects was semiquantitatively analyzed using Reverse Transcriptase Polymerase Chain Reaction (RT-PCR).
Results.
The present study demonstrated the expression of IL-35 mRNA in gingival tissues of all the three groups.
IL-35 mRNA expression was highest in chronic periodontitis subjects (6.87±2.32) as compared to the aggressive periodontitis group (4.71±1.43) and least seen in healthy patients (3.03±1.91).
Conclusion.
The increased expression of IL-35 in chronic and aggressive periodontitis suggests its possible role in pathogenesis of periodontitis.
Future studies done on large samples with intervention will strengthen our result.
American Psychological Association (APA)
Kalburgi, Nagaraj B.& Muley, Akshay& Shivaprasad, B. M.& Koregol, Arati C.. 2013. Expression Profile of IL-35 mRNA in Gingiva of Chronic Periodontitis and Aggressive Periodontitis Patients: A Semiquantitative RT-PCR Study. Disease Markers،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1005831
Modern Language Association (MLA)
Kalburgi, Nagaraj B.…[et al.]. Expression Profile of IL-35 mRNA in Gingiva of Chronic Periodontitis and Aggressive Periodontitis Patients: A Semiquantitative RT-PCR Study. Disease Markers No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1005831
American Medical Association (AMA)
Kalburgi, Nagaraj B.& Muley, Akshay& Shivaprasad, B. M.& Koregol, Arati C.. Expression Profile of IL-35 mRNA in Gingiva of Chronic Periodontitis and Aggressive Periodontitis Patients: A Semiquantitative RT-PCR Study. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1005831
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005831