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Effect of Surgical Treatment on Lipid Peroxidation Parameters and Antioxidant Status in the Serum of Patients with Peripheral Arterial Disease
Joint Authors
Strzyżewski, Krzysztof Wojciech
Pioruńska-Stolzmann, Maria
Majewski, Wacław
Kasprzak, Magdalena
Strzyżewski, Wojciech
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The various risk factors for peripheral arterial disease (PAD) are almost identical to those for atherosclerosis and include abnormal levels of lipids or lipoproteins.
Lipid peroxidation parameters and total antioxidant capacity in the serum of male patients with PAD before surgery as well as 3–5 days and 7–10 days after surgery were measured.
We also compared these parameters with those in a group of patients receiving simvastatin therapy.
Concentrations of lipid hydroperoxides (LOOHs) and malondialdehyde, the total antioxidant capacity (assessed by ferric reducing antioxidant power assay), concentration of thiol (-SH) groups, and ceruloplasmin activity were determined spectrophotometrically in PAD patients treated surgically (Group I) or pharmacologically (Group II).
The patients before surgical treatment had significantly higher concentrations of malondialdehyde but lower ceruloplasmin activity than those observed in Group II, treated with simvastatin.
No significant differences before surgery in ferric reducing antioxidant power or thiol concentrations were found between the two groups.
However, in Group I, both ferric reducing antioxidant power and thiol group concentrations decreased 3–5 days postoperatively, and ceruloplasmin activity increased 7–10 days after surgical treatment.
The presented results demonstrate diverse oxidative stress responses to surgical treatment and confirm the beneficial effects of statin therapy in PAD.
American Psychological Association (APA)
Strzyżewski, Krzysztof Wojciech& Pioruńska-Stolzmann, Maria& Majewski, Wacław& Kasprzak, Magdalena& Strzyżewski, Wojciech. 2013. Effect of Surgical Treatment on Lipid Peroxidation Parameters and Antioxidant Status in the Serum of Patients with Peripheral Arterial Disease. Disease Markers،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1005839
Modern Language Association (MLA)
Strzyżewski, Krzysztof Wojciech…[et al.]. Effect of Surgical Treatment on Lipid Peroxidation Parameters and Antioxidant Status in the Serum of Patients with Peripheral Arterial Disease. Disease Markers No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1005839
American Medical Association (AMA)
Strzyżewski, Krzysztof Wojciech& Pioruńska-Stolzmann, Maria& Majewski, Wacław& Kasprzak, Magdalena& Strzyżewski, Wojciech. Effect of Surgical Treatment on Lipid Peroxidation Parameters and Antioxidant Status in the Serum of Patients with Peripheral Arterial Disease. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1005839
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005839