Overexpression of FXYD-3 Is Involved in the Tumorigenesis and Development of Esophageal Squamous Cell Carcinoma

Abstract EN

To investigate the association of FXYD-3 expression with clinicopathological variables and PINCH in patients with ESCC.

Patients and Methods.

Expression of FXYD-3 protein was immunohistochemically examined in normal esophageal mucous (n=20) and ESCC (n=64).

Results.

Expression of FXYD-3 in the cytoplasm markedly increased from normal esophageal epithelial cells to primary ESCC (P=0.001).

The expression of FXYD-3 was correlated with TNM stages and depth of tumor invasion.

Furthermore, the cases with lymph node metastasis tended to show a higher frequency of positive expression than those without metastasis (P=0.086), and FXYD-3 expression tended to be positively related to the expression of PINCH (P=0.063).

Moreover, the cases positive for both proteins had the highest frequency of lymph node metastasis (P=0.001).

However, FXYD-3 expression was not correlated with patient’s gender (P=0.847), age (P=0.876), tumor location (P=0.279), size (P=0.771), grade of differentiation (P=0.279), and survival (P=0.113).

Conclusion.

Overexpression of FXYD-3 in the cytoplasm may play an important role in the tumorigenesis and development in the human ESCC, particularly in combination with PINCH expression.