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Investigation of Genetic Polymorphisms Related to the Outcome of Radiotherapy for Prostate Cancer Patients
Joint Authors
Cintra, Hellen Silva
Pinezi, Juliana Castro Dourado
Machado, Graziella Dias Pinheiro
Carvalho, Gustavo Moura de
Carvalho, Ana Terra Silva
dos Santos, Thalles Eduardo Dias
Marciano, Ricardo Duarte
Soares, Renata de Bastos Ascenço
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The purpose of this study was to evaluate the association between ATM, TP53 and MDM2 polymorphisms in prostate cancer patients and morbidity after radiotherapy.
The presence of ATM (rs1801516), TP53 (rs1042522, rs1800371, rs17878362, rs17883323, and rs35117667), and MDM2 (rs2279744) polymorphisms was assessed by direct sequencing of PCR fragments from 48 patients with histologically proven prostate adenocarcinoma and treated with external beam radiation.
The side effects were classified according to the Radiation Therapy Oncology Group (RTOG) score.
The results showed no association between clinical characteristics and the development of radiation toxicities (P > 0.05).
The C>T transition in the position 16273 (intron 3) of TP53 (rs35117667) was significantly associated with the risk of acute skin toxicity (OR: 0.0072, 95% CI 0.0002–0.227, P = 0.003).
The intronic TP53 polymorphism at position 16250 (rs17883323) was associated with chronic urinary toxicity (OR: 0.071, 95%CI 0.006–0.784, P = 0.032).
No significant associations were found for the remaining polymorphisms (P > 0.05).
The results show that clinical characteristics were not determinant on the developing of radiation sensitivity in prostate cancer patients, and intronic TP53 polymorphisms would be associated with increased acute and chronic radiation toxicities.
These observations corroborate the importance of investigating the genetic profile to predict adverse side effects in patients undergoing radiotherapy.
American Psychological Association (APA)
Cintra, Hellen Silva& Pinezi, Juliana Castro Dourado& Machado, Graziella Dias Pinheiro& Carvalho, Gustavo Moura de& Carvalho, Ana Terra Silva& dos Santos, Thalles Eduardo Dias…[et al.]. 2013. Investigation of Genetic Polymorphisms Related to the Outcome of Radiotherapy for Prostate Cancer Patients. Disease Markers،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1005868
Modern Language Association (MLA)
Cintra, Hellen Silva…[et al.]. Investigation of Genetic Polymorphisms Related to the Outcome of Radiotherapy for Prostate Cancer Patients. Disease Markers No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1005868
American Medical Association (AMA)
Cintra, Hellen Silva& Pinezi, Juliana Castro Dourado& Machado, Graziella Dias Pinheiro& Carvalho, Gustavo Moura de& Carvalho, Ana Terra Silva& dos Santos, Thalles Eduardo Dias…[et al.]. Investigation of Genetic Polymorphisms Related to the Outcome of Radiotherapy for Prostate Cancer Patients. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1005868
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005868