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Association of a FGFR-4 Gene Polymorphism with Bronchopulmonary Dysplasia and Neonatal Respiratory Distress
Joint Authors
Rezvani, Milad
Wilde, Juliane
Vitt, Patricia
Mailaparambil, Beena
Grychtol, Ruth
Krueger, Marcus
Heinzmann, Andrea
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease of premature birth, characterized by impaired alveolar development and inflammation.
Pathomechanisms contributing to BPD are poorly understood.
However, it is assumed that genetic factors predispose to BPD and other pulmonary diseases of preterm neonates, such as neonatal respiratory distress syndrome (RDS).
For association studies, genes upregulated during alveolarization are major candidates for genetic analysis, for example, matrix metalloproteinases (MMPs) and fibroblast growth factors (FGFs) and their receptors (FGFR).
Objective.
Determining genetic risk variants in a Caucasian population of premature neonates with BPD and RDS.
Methods.
We genotyped 27 polymorphisms within 14 candidate genes via restriction fragment length polymorphism (RFLP): MMP-1, -2, -9, and -12, -16, FGF receptors 2 and 4, FGF-2, -3, -4, -7, and -18, Signal-Regulatory Protein α (SIRPA) and Thyroid Transcription Factor-1 (TTF-1).
Results.
Five single nucleotide polymorphisms (SNPs) in MMP-9, MMP-12, FGFR-4, FGF-3, and FGF-7 are associated (P<0.05) with RDS, defined as surfactant application within the first 24 hours after birth.
One of them, in FGFR-4 (rs1966265), is associated with both RDS (P=0.003) and BPD (P=0.023).
Conclusion.
rs1966265 in FGF receptor 4 is a possible genetic key variant in alveolar diseases of preterm newborns.
American Psychological Association (APA)
Rezvani, Milad& Wilde, Juliane& Vitt, Patricia& Mailaparambil, Beena& Grychtol, Ruth& Krueger, Marcus…[et al.]. 2013. Association of a FGFR-4 Gene Polymorphism with Bronchopulmonary Dysplasia and Neonatal Respiratory Distress. Disease Markers،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1005894
Modern Language Association (MLA)
Rezvani, Milad…[et al.]. Association of a FGFR-4 Gene Polymorphism with Bronchopulmonary Dysplasia and Neonatal Respiratory Distress. Disease Markers No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1005894
American Medical Association (AMA)
Rezvani, Milad& Wilde, Juliane& Vitt, Patricia& Mailaparambil, Beena& Grychtol, Ruth& Krueger, Marcus…[et al.]. Association of a FGFR-4 Gene Polymorphism with Bronchopulmonary Dysplasia and Neonatal Respiratory Distress. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1005894
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005894