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Local and Systemic Inflammatory Responses to Experimentally Induced Gingivitis
Joint Authors
Leishman, Shaneen J.
Seymour, Gregory J.
Ford, Pauline J.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This study profiled the local and systemic inflammatory responses to experimentally induced gingivitis.
Eight females participated in a 21-day experimental gingivitis model followed by a 14-day resolution phase.
Bleeding on probing and plaque index scores were assessed before, during, and after resolution of gingival inflammation, and samples of saliva, GCF, and plasma were collected.
Samples were assessed for biomarkers of inflammation using the BioPlex platform and ELISA.
There were no significant changes in GCF levels of cytokines during the experimental phase; however, individual variability in cytokine profiles was noted.
During resolution, mean GCF levels of IL-2, IL-6, and TNF-α decreased and were significantly lower than baseline levels (P=0.003, P=0.025, and P=0.007, resp.).
Furthermore, changes in GCF levels of IL-2, IL-6, and TNF-α during resolution correlated with changes in plaque index scores (r=0.88, P=0.004; r=0.72, P=0.042; r=0.79, P=0.019, resp.).
Plasma levels of sICAM-1 increased significantly during the experimental phase (P=0.002) and remained elevated and significantly higher than baseline levels during resolution (P<0.001).
These results support the concept that gingivitis adds to the systemic inflammatory burden of an individual.
American Psychological Association (APA)
Leishman, Shaneen J.& Seymour, Gregory J.& Ford, Pauline J.. 2013. Local and Systemic Inflammatory Responses to Experimentally Induced Gingivitis. Disease Markers،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1005896
Modern Language Association (MLA)
Leishman, Shaneen J.…[et al.]. Local and Systemic Inflammatory Responses to Experimentally Induced Gingivitis. Disease Markers No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1005896
American Medical Association (AMA)
Leishman, Shaneen J.& Seymour, Gregory J.& Ford, Pauline J.. Local and Systemic Inflammatory Responses to Experimentally Induced Gingivitis. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1005896
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005896