Altered Peptidase Activities in Thyroid Neoplasia and Hyperplasia
Joint Authors
Larrinaga, Gorka
Blanco, Lorena
Errarte, Peio
Beitia, Maider
Sanz, Begoña
Perez, Itxaro
Irazusta, Amaia
Sánchez, Clara E.
Santaolalla, Francisco
Andrés, Leire
López, José I.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Papillary thyroid carcinoma (PTC), follicular thyroid adenoma (FTA), and thyroid nodular hyperplasia (TNH) are the most frequent diseases of the thyroid gland.
Previous studies described the involvement of dipeptidyl-peptidase IV (DPPIV/CD26) in the development of thyroid neoplasia and proposed it as an additional tool in the diagnosis/prognosis of these diseases.
However, very little is known about the involvement of other peptidases in neoplastic and hyperplastic processes of this gland.
Methods.
The catalytic activity of 10 peptidases in a series of 30 PTC, 10 FTA, and 14 TNH was measured fluorimetrically in tumour and nontumour adjacent tissues.
Results.
The activity of DPPIV/CD26 was markedly higher in PTC than in FTA, TNH, and nontumour tissues.
Aspartyl aminopeptidase (AspAP), alanyl aminopeptidase (AlaAP), prolyl endopeptidase, pyroglutamyl peptidase I, and aminopeptidase B activities were significantly increased in thyroid neoplasms when compared to nontumour tissues.
AspAP and AlaAP activities were also significantly higher in PTC than in FTA and TNH.
Conclusions.
These data suggest the involvement of DPPIV/CD26 and some cytosolic peptidases in the neoplastic development of PTC and FTA.
Further studies will help to define the possible clinical usefulness of AlaAP and AspAP in the diagnosis/prognosis of thyroid neoplasms.
American Psychological Association (APA)
Larrinaga, Gorka& Blanco, Lorena& Errarte, Peio& Beitia, Maider& Sanz, Begoña& Perez, Itxaro…[et al.]. 2013. Altered Peptidase Activities in Thyroid Neoplasia and Hyperplasia. Disease Markers،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1005900
Modern Language Association (MLA)
Larrinaga, Gorka…[et al.]. Altered Peptidase Activities in Thyroid Neoplasia and Hyperplasia. Disease Markers No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1005900
American Medical Association (AMA)
Larrinaga, Gorka& Blanco, Lorena& Errarte, Peio& Beitia, Maider& Sanz, Begoña& Perez, Itxaro…[et al.]. Altered Peptidase Activities in Thyroid Neoplasia and Hyperplasia. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1005900
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005900