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Oxidative Stress-Related Biomarkers in Essential Hypertension and Ischemia-Reperfusion Myocardial Damage
Joint Authors
Rodrigo, Ramón
Libuy, Matías
Feliú, Felipe
Hasson, Daniel
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-21
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Cardiovascular diseases are a leading cause of mortality and morbidity worldwide, with hypertension being a major risk factor.
Numerous studies support the contribution of reactive oxygen and nitrogen species in the pathogenesis of hypertension, as well as other pathologies associated with ischemia/reperfusion.
However, the validation of oxidative stress-related biomarkers in these settings is still lacking and novel association of these biomarkers and other biomarkers such as endothelial progenitor cells, endothelial microparticles, and ischemia modified albumin, is just emerging.
Oxidative stress has been suggested as a pathogenic factor and therapeutic target in early stages of essential hypertension.
Systolic and diastolic blood pressure correlated positively with plasma F2-isoprostane levels and negatively with total antioxidant capacity of plasma in hypertensive and normotensive patients.
Cardiac surgery with extracorporeal circulation causes an ischemia/reperfusion event associated with increased lipid peroxidation and protein carbonylation, two biomarkers associated with oxidative damage of cardiac tissue.
An enhancement of the antioxidant defense system should contribute to ameliorating functional and structural abnormalities derived from this metabolic impairment.
However, data have to be validated with the analysis of the appropriate oxidative stress and/or nitrosative stress biomarkers.
American Psychological Association (APA)
Rodrigo, Ramón& Libuy, Matías& Feliú, Felipe& Hasson, Daniel. 2013. Oxidative Stress-Related Biomarkers in Essential Hypertension and Ischemia-Reperfusion Myocardial Damage. Disease Markers،Vol. 2013, no. 2013, pp.1-18.
https://search.emarefa.net/detail/BIM-1005901
Modern Language Association (MLA)
Rodrigo, Ramón…[et al.]. Oxidative Stress-Related Biomarkers in Essential Hypertension and Ischemia-Reperfusion Myocardial Damage. Disease Markers No. 2013 (2013), pp.1-18.
https://search.emarefa.net/detail/BIM-1005901
American Medical Association (AMA)
Rodrigo, Ramón& Libuy, Matías& Feliú, Felipe& Hasson, Daniel. Oxidative Stress-Related Biomarkers in Essential Hypertension and Ischemia-Reperfusion Myocardial Damage. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-18.
https://search.emarefa.net/detail/BIM-1005901
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005901