Increased LEF1 Expression and Decreased Notch2 Expression Are Strong Predictors of Poor Outcomes in Colorectal Cancer Patients
Joint Authors
Wang, Wen-Juan
Yao, Yu
Jiang, Li-Li
Hu, Ting-Hua
Ma, Jie-Qun
Ruan, Zhi-Ping
Tian, Tao
Guo, Hui
Wang, Shu-Hong
Nan, Ke-Jun
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
We aimed to examine the expression of lymphoid enhancer factor 1 (LEF1) and Notch2 in colorectal cancer (CRC) and their association with clinicopathologic variables and CRC patients’ prognosis.
Methods.
Immunohistochemistry, quantitative real-time polymerase chain reaction (qRT-PCR), and Western blot analysis were performed to assess the expression of LEF1 and Notch2 in 184 patients with CRC.
Results.
We observed a strong negative correlation between LEF1 expression and Notch2 expression (P<0.001).
Both LEF1 mRNA and protein expression increased while the Notch2 mRNA and protein expression decreased in tumor specimens compared with the matched paratumorous normal tissue (P<0.001).
An increase in LEF1 protein expression was significantly associated with lymph node metastases, distant metastasis, advanced TNM (tumor-node-metastasis) stage, and shorter overall survival.
A decrease in Notch2 protein expression was associated with poorly differentiated tumors, lymph node metastases, distant metastasis, advanced TNM stage, and shorter overall survival of patients.
In the multivariate Cox regression analysis, the LEF1 protein expression (P<0.001), Notch2 protein expression (P<0.001), TNM stage (P<0.001), and the combination of increased LEF1 protein coexpression and decreased Notch2 protein coexpression (P<0.001) were found to be independent prognostic indicators in CRC.
Conclusion.
Our results suggest that increased LEF1 coexpression and decreased Notch2 coexpression represent a risk factor for poor overall survival of CRC patients.
American Psychological Association (APA)
Wang, Wen-Juan& Yao, Yu& Jiang, Li-Li& Hu, Ting-Hua& Ma, Jie-Qun& Ruan, Zhi-Ping…[et al.]. 2013. Increased LEF1 Expression and Decreased Notch2 Expression Are Strong Predictors of Poor Outcomes in Colorectal Cancer Patients. Disease Markers،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1005903
Modern Language Association (MLA)
Wang, Wen-Juan…[et al.]. Increased LEF1 Expression and Decreased Notch2 Expression Are Strong Predictors of Poor Outcomes in Colorectal Cancer Patients. Disease Markers No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1005903
American Medical Association (AMA)
Wang, Wen-Juan& Yao, Yu& Jiang, Li-Li& Hu, Ting-Hua& Ma, Jie-Qun& Ruan, Zhi-Ping…[et al.]. Increased LEF1 Expression and Decreased Notch2 Expression Are Strong Predictors of Poor Outcomes in Colorectal Cancer Patients. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1005903
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005903