Dextromethorphan Inhibits Activations and Functions in Dendritic Cells
Joint Authors
Chen, Der-Yuan
Chen, Yi-Ming
Lin, Sheng-Hao
Hong, Jau-Shyong
Lin, Ching-Hsiung
Chu, Ching-Liang
Song, Pei-Shan
Lin, Chi-Chen
Pan, I-Horng
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Dendritic cells (DCs) play an important role in connecting innate and adaptive immunity.
Thus, DCs have been regarded as a major target for the development of immunomodulators.
In this study, we examined the effect of dextromethorphan (DXM), a common cough suppressant with a high safety profile, on the activation and function of DCs.
In the presence of DXM, the LPS-induced expression of the costimulatory molecules in murine bone marrow-derived dendritic cells (BMDCs) was significantly suppressed.
In addition, DXM treatment reduced the production of reactive oxygen species (ROS), proinflammatory cytokines, and chemokines in maturing BMDCs that were activated by LPS.
Therefore, DXM abrogated the ability of LPS-stimulated DCs to induce Ag-specific T-cell activation, as determined by their decreased proliferation and IFN-γ secretion in mixed leukocyte cultures.
Moreover, the inhibition of LPS-induced MAPK activation and NF-κB translocation may contribute to the suppressive effect of DXM on BMDCs.
Remarkably, DXM decreased the LPS-induced surface expression of CD80, CD83, and HLA-DR and the secretion of IL-6 and IL-12 in human monocyte-derived dendritic cells (MDDCs).
These findings provide a new insight into the impact of DXM treatment on DCs and suggest that DXM has the potential to be used in treating DC-related acute and chronic diseases.
American Psychological Association (APA)
Chen, Der-Yuan& Song, Pei-Shan& Hong, Jau-Shyong& Chu, Ching-Liang& Pan, I-Horng& Chen, Yi-Ming…[et al.]. 2013. Dextromethorphan Inhibits Activations and Functions in Dendritic Cells. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1006435
Modern Language Association (MLA)
Chen, Der-Yuan…[et al.]. Dextromethorphan Inhibits Activations and Functions in Dendritic Cells. Journal of Immunology Research No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1006435
American Medical Association (AMA)
Chen, Der-Yuan& Song, Pei-Shan& Hong, Jau-Shyong& Chu, Ching-Liang& Pan, I-Horng& Chen, Yi-Ming…[et al.]. Dextromethorphan Inhibits Activations and Functions in Dendritic Cells. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1006435
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006435