p53p21 Pathway Involved in Mediating Cellular Senescence of Bone Marrow-Derived Mesenchymal Stem Cells from Systemic Lupus Erythematosus Patients
Joint Authors
Cao, Haixia
Xia, Yunfei
Tan, Wei
Meng, Yan
Gu, Zhifeng
Cheng, Chun
Liu, Hong
Jiang, Jinxia
Da, Zhanyun
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-16
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Our and other groups have found that bone marrow-derived mesenchymal stem cells (BM-MSCs) from systemic lupus erythematosus (SLE) patients exhibited senescent behavior and are involved in the pathogenesis of SLE.
Numerous studies have shown that activation of the p53/p21 pathway inhibits the proliferation of BM-MSCs.
The aim of this study was to determine whether p53/p21 pathway is involved in regulating the aging of BM-MSCs from SLE patients and the underlying mechanisms.
We further confirmed that BM-MSCs from SLE patients showed characteristics of senescence.
The expressions of p53 and p21 were significantly increased, whereas levels of Cyclin E, cyclin-dependent kinase-2, and phosphorylation of retinoblastoma protein were decreased in the BM-MSCs from SLE patients and knockdown of p21 expression reversed the senescent features of BM-MSCs from SLE patients.
Our results demonstrated that p53/p21 pathway played an important role in the senescence process of BM-MSCs from SLE.
American Psychological Association (APA)
Gu, Zhifeng& Jiang, Jinxia& Tan, Wei& Xia, Yunfei& Cao, Haixia& Meng, Yan…[et al.]. 2013. p53p21 Pathway Involved in Mediating Cellular Senescence of Bone Marrow-Derived Mesenchymal Stem Cells from Systemic Lupus Erythematosus Patients. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1006447
Modern Language Association (MLA)
Gu, Zhifeng…[et al.]. p53p21 Pathway Involved in Mediating Cellular Senescence of Bone Marrow-Derived Mesenchymal Stem Cells from Systemic Lupus Erythematosus Patients. Journal of Immunology Research No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-1006447
American Medical Association (AMA)
Gu, Zhifeng& Jiang, Jinxia& Tan, Wei& Xia, Yunfei& Cao, Haixia& Meng, Yan…[et al.]. p53p21 Pathway Involved in Mediating Cellular Senescence of Bone Marrow-Derived Mesenchymal Stem Cells from Systemic Lupus Erythematosus Patients. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1006447
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006447
