Association of Human Leukocyte Antigen Class I Polymorphism with Spontaneous Clearance of Hepatitis B Surface Antigen in Qidong Han Population
Joint Authors
Miao, Fengqin
Xie, Wei
Sun, Hang
Zhang, Jianqiong
Qiu, Jie
Pan, Ning
Shen, Yuqing
Xu, Jinhuan
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aim.
To investigate whether HLA class I polymorphisms could influence the clearance of hepatitis B surface antigen (HBsAg) in Qidong Han population.
Methods.
We genotyped HLA-A, -B, and -C loci of 448 individuals with HBV persistent infection and 140 persons with spontaneous clearance of HBsAg by polymerase chain reaction with sequencing based typing (PCR/SBT).
All the individuals were unrelated males enrolled from Qidong Han population and were followed up for 10 years.
Results.
The frequency of HLA-A*33:03:01G was increased in persistent HBV infection group (P value is 0.028), while frequency of HLA-B*13:01:01G was increased in HBsAg clearance group (P value is 0.0004).
Conclusion.
These findings suggested that the host HLA class I polymorphism is an important factor in determining the outcomes of HBV infection.
American Psychological Association (APA)
Miao, Fengqin& Sun, Hang& Pan, Ning& Xu, Jinhuan& Qiu, Jie& Shen, Yuqing…[et al.]. 2013. Association of Human Leukocyte Antigen Class I Polymorphism with Spontaneous Clearance of Hepatitis B Surface Antigen in Qidong Han Population. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1006451
Modern Language Association (MLA)
Miao, Fengqin…[et al.]. Association of Human Leukocyte Antigen Class I Polymorphism with Spontaneous Clearance of Hepatitis B Surface Antigen in Qidong Han Population. Journal of Immunology Research No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1006451
American Medical Association (AMA)
Miao, Fengqin& Sun, Hang& Pan, Ning& Xu, Jinhuan& Qiu, Jie& Shen, Yuqing…[et al.]. Association of Human Leukocyte Antigen Class I Polymorphism with Spontaneous Clearance of Hepatitis B Surface Antigen in Qidong Han Population. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1006451
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006451