Role of Microglia in CNS Autoimmunity
Joint Authors
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Multiple sclerosis (MS) is the most common autoimmune disease of the central nervous system (CNS) in the Western world.
The disease is characterized histologically by the infiltration of encephalitogenic TH1/TH17-polarized CD4+ T cells, B cells, and a plethora of myeloid cells, resulting in severe demyelination ultimately leading to a degeneration of neuronal structures.
These pathological processes are substantially modulated by microglia, the resident immune competent cells of the CNS.
In this overview, we summarize the current knowledge regarding the highly diverse and complex function of microglia during CNS autoimmunity in either promoting tissue injury or tissue repair.
Hence, understanding microglia involvement in MS offers new exciting paths for therapeutic intervention.
American Psychological Association (APA)
Goldmann, Tobias& Prinz, Marco. 2013. Role of Microglia in CNS Autoimmunity. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1006495
Modern Language Association (MLA)
Goldmann, Tobias& Prinz, Marco. Role of Microglia in CNS Autoimmunity. Journal of Immunology Research No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1006495
American Medical Association (AMA)
Goldmann, Tobias& Prinz, Marco. Role of Microglia in CNS Autoimmunity. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1006495
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006495