Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance
Joint Authors
Saez, Juan Jose
Sauma, Daniela
Nuñez, Sarah
Silva, Cinthia
Rosemblatt, Mario
Maldonado, Paula
Hidalgo, Yessia
Ruiz, Paulina
Gleisner, Alejandra
Bono, María Rosa
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-12
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
One of the greatest advances in medicine during the past century is the introduction of organ transplantation.
This therapeutic strategy designed to treat organ failure and organ dysfunction allows to prolong the survival of many patients that are faced with no other treatment option.
Today, organ transplantation between genetically dissimilar individuals (allogeneic grafting) is a procedure widely used as a therapeutic alternative in cases of organ failure, hematological disease treatment, and some malignancies.
Despite the potential of organ transplantation, the administration of immunosuppressive drugs required for allograft acceptance induces severe immunosuppression in transplanted patients, which leads to serious side effects such as infection with opportunistic pathogens and the occurrence of neoplasias, in addition to the known intrinsic toxicity of these drugs.
To solve this setback in allotransplantation, researchers have focused on manipulating the immune response in order to create a state of tolerance rather than unspecific immunosuppression.
Here, we describe the different treatments and some of the novel immunotherapeutic strategies undertaken to induce transplantation tolerance.
American Psychological Association (APA)
Ruiz, Paulina& Maldonado, Paula& Hidalgo, Yessia& Gleisner, Alejandra& Sauma, Daniela& Silva, Cinthia…[et al.]. 2013. Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-1006497
Modern Language Association (MLA)
Ruiz, Paulina…[et al.]. Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance. Journal of Immunology Research No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-1006497
American Medical Association (AMA)
Ruiz, Paulina& Maldonado, Paula& Hidalgo, Yessia& Gleisner, Alejandra& Sauma, Daniela& Silva, Cinthia…[et al.]. Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-1006497
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006497