Autoantibodies and the Immune Hypothesis in Psychotic Brain Diseases: Challenges and Perspectives
Joint Authors
Pathmanandavel, Karrnan
Starling, Jean
Brilot, Fabienne
Dale, Russell C.
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The pathophysiology of psychosis is poorly understood, with both the cognitive and cellular changes of the disease process remaining mysterious.
There is a growing body of evidence that points to dysfunction of the immune system in a subgroup of patients with psychosis.
Recently, autoantibodies directed against neuronal cell surface targets have been identified in a range of syndromes that feature psychosis.
Of interest is the detection of autoantibodies in patients whose presentations are purely psychiatric, such as those suffering from schizophrenia.
Autoantibodies have been identified in a minority of patients, suggesting that antibody-associated mechanisms of psychiatric disease likely only account for a subgroup of cases.
Recent work has been based on the application of cell-based assays—a paradigm whose strength lies in the expression of putative antigens in their natural conformation on the surface of live cells.
The responsiveness of some of these newly described clinical syndromes to immune therapy supports the hypothesis that antibody-associated mechanisms play a role in the pathogenesis of psychotic disease.
However, further investigation is required to establish the scope and significance of antibody pathology in psychosis.
The identification of a subgroup of patients with antibody-mediated disease would promise more effective approaches to the treatment of these high-morbidity conditions.
American Psychological Association (APA)
Pathmanandavel, Karrnan& Starling, Jean& Dale, Russell C.& Brilot, Fabienne. 2013. Autoantibodies and the Immune Hypothesis in Psychotic Brain Diseases: Challenges and Perspectives. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1006511
Modern Language Association (MLA)
Pathmanandavel, Karrnan…[et al.]. Autoantibodies and the Immune Hypothesis in Psychotic Brain Diseases: Challenges and Perspectives. Journal of Immunology Research No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1006511
American Medical Association (AMA)
Pathmanandavel, Karrnan& Starling, Jean& Dale, Russell C.& Brilot, Fabienne. Autoantibodies and the Immune Hypothesis in Psychotic Brain Diseases: Challenges and Perspectives. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1006511
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006511