Prediction of IL4 Inducing Peptides
Joint Authors
Vir, Pooja
Dhanda, Sandeep Kumar
Raghava, Gajendra P. S.
Gupta, Sudheer
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The secretion of Interleukin-4 (IL4) is the characteristic of T-helper 2 responses.
IL4 is a cytokine produced by CD4+ T cells in response to helminthes and other extracellular parasites.
It has a critical role in guiding antibody class switching, hematopoiesis and inflammation, and the development of appropriate effector T-cell responses.
In this study, it is the first time an attempt has been made to understand whether it is possible to predict IL4 inducing peptides.
The data set used in this study comprises 904 experimentally validated IL4 inducing and 742 noninducing MHC class II binders.
Our analysis revealed that certain types of residues are preferred at certain positions in IL4 inducing peptides.
It was also observed that IL4 inducing and noninducing epitopes differ in compositional and motif pattern.
Based on our analysis we developed classification models where the hybrid method of amino acid pairs and motif information performed the best with maximum accuracy of 75.76% and MCC of 0.51.
These results indicate that it is possible to predict IL4 inducing peptides with reasonable precession.
These models would be useful in designing the peptides that may induce desired Th2 response.
American Psychological Association (APA)
Dhanda, Sandeep Kumar& Gupta, Sudheer& Vir, Pooja& Raghava, Gajendra P. S.. 2013. Prediction of IL4 Inducing Peptides. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1006520
Modern Language Association (MLA)
Dhanda, Sandeep Kumar…[et al.]. Prediction of IL4 Inducing Peptides. Journal of Immunology Research No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1006520
American Medical Association (AMA)
Dhanda, Sandeep Kumar& Gupta, Sudheer& Vir, Pooja& Raghava, Gajendra P. S.. Prediction of IL4 Inducing Peptides. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1006520
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006520