The Impact of the Myeloid Response to Radiation Therapy
Joint Authors
Young, Kristina
Gough, Michael J.
Crittenden, Marka
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-07
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Radiation therapy is showing potential as a partner for immunotherapies in preclinical cancer models and early clinical studies.
As has been discussed elsewhere, radiation provides debulking, antigen and adjuvant release, and inflammatory targeting of effector cells to the treatment site, thereby assisting multiple critical checkpoints in antitumor adaptive immunity.
Adaptive immunity is terminated by inflammatory resolution, an active process which ensures that inflammatory damage is repaired and tissue function is restored.
We discuss how radiation therapy similarly triggers inflammation followed by repair, the consequences to adaptive immune responses in the treatment site, and how the myeloid response to radiation may impact immunotherapies designed to improve control of residual cancer cells.
American Psychological Association (APA)
Gough, Michael J.& Young, Kristina& Crittenden, Marka. 2013. The Impact of the Myeloid Response to Radiation Therapy. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1006580
Modern Language Association (MLA)
Gough, Michael J.…[et al.]. The Impact of the Myeloid Response to Radiation Therapy. Journal of Immunology Research No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-1006580
American Medical Association (AMA)
Gough, Michael J.& Young, Kristina& Crittenden, Marka. The Impact of the Myeloid Response to Radiation Therapy. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1006580
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006580