Prolactin Levels Correlate with Abnormal B Cell Maturation in MRL and MRLlpr Mouse Models of Systemic Lupus Erythematosus-Like Disease
Joint Authors
Blanco-Favela, Francisco
Legorreta-Haquet, Maria Victoria
Arriaga-Pizano, Lourdes
Flores-Fernández, Rocio
Tesoro-Cruz, Emiliano
Hernández-González, Rafael
Chávez-Rueda, Adriana Karina
Chávez-Sánchez, Luis
Fuentes-Pananá, Ezequiel M.
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Prolactin (PRL) plays an important role in modulating the immune response.
In B cells, PRL enhances antibody production, including antibodies with self-specificity.
In this study, our aims were to determine the level of PRL receptor expression during bone-marrow B-cell development and to assess whether the presence of high PRL serum concentrations influences absolute numbers of developing populations and disease outcome in lupus-prone murine models.
We observed that the PRL-receptor is expressed in early bone-marrow B-cell; the expression in lupus-prone mice, which had the highest level of expression in pro-B cells and immature cells, differed from that in wild-type mice.
These expression levels did not significantly change in response to hyperprolactinemia; however, populations of pro-B and immature cells from lupus-prone strains showed a decrease in the absolute numbers of cells with high PRL-receptor expression in response to PRL.
Because immature self-reactive B cells are constantly being eliminated, we assessed the expression of survival factor BIRC5, which is more highly expressed in both pro-B and immature B-cells in response to PRL and correlates with the onset of disease.
These results identify an important role of PRL in the early stages of the B-cell maturation process: PRL may promote the survival of self-reactive clones.
American Psychological Association (APA)
Legorreta-Haquet, Maria Victoria& Flores-Fernández, Rocio& Blanco-Favela, Francisco& Fuentes-Pananá, Ezequiel M.& Chávez-Sánchez, Luis& Hernández-González, Rafael…[et al.]. 2013. Prolactin Levels Correlate with Abnormal B Cell Maturation in MRL and MRLlpr Mouse Models of Systemic Lupus Erythematosus-Like Disease. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1006588
Modern Language Association (MLA)
Legorreta-Haquet, Maria Victoria…[et al.]. Prolactin Levels Correlate with Abnormal B Cell Maturation in MRL and MRLlpr Mouse Models of Systemic Lupus Erythematosus-Like Disease. Journal of Immunology Research No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1006588
American Medical Association (AMA)
Legorreta-Haquet, Maria Victoria& Flores-Fernández, Rocio& Blanco-Favela, Francisco& Fuentes-Pananá, Ezequiel M.& Chávez-Sánchez, Luis& Hernández-González, Rafael…[et al.]. Prolactin Levels Correlate with Abnormal B Cell Maturation in MRL and MRLlpr Mouse Models of Systemic Lupus Erythematosus-Like Disease. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1006588
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006588