Cellular Mechanisms of Multiple Myeloma Bone Disease
Joint Authors
Izzo, Maddalena
Grano, Maria
Carbone, Claudia
Oranger, Angela
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Multiple myeloma (MM) is a hematologic malignancy of differentiated plasma cells that accumulates and proliferates in the bone marrow.
MM patients often develop bone disease that results in severe bone pain, osteolytic lesions, and pathologic fractures.
These skeletal complications have not only a negative impact on quality of life but also a possible effect in overall survival.
MM osteolytic bone lesions arise from the altered bone remodeling due to both increased osteoclast activation and decreased osteoblast differentiation.
A dysregulated production of numerous cytokines that can contribute to the uncoupling of bone cell activity is well documented in the bone marrow microenvironment of MM patients.
These molecules are produced not only by malignant plasma cells, that directly contribute to MM bone disease, but also by bone, immune, and stromal cells interacting with each other in the bone microenvironment.
This review focuses on the current knowledge of MM bone disease biology, with particular regard on the role of bone and immune cells in producing cytokines critical for malignant plasma cell proliferation as well as in osteolysis development.
Therefore, the understanding of MM pathogenesis could be useful to the discovery of novel agents that will be able to both restore bone remodelling and reduce tumor burden.
American Psychological Association (APA)
Oranger, Angela& Carbone, Claudia& Izzo, Maddalena& Grano, Maria. 2013. Cellular Mechanisms of Multiple Myeloma Bone Disease. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1006591
Modern Language Association (MLA)
Oranger, Angela…[et al.]. Cellular Mechanisms of Multiple Myeloma Bone Disease. Journal of Immunology Research No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1006591
American Medical Association (AMA)
Oranger, Angela& Carbone, Claudia& Izzo, Maddalena& Grano, Maria. Cellular Mechanisms of Multiple Myeloma Bone Disease. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1006591
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006591