Sphingolipids and Brain Resident Macrophages in Neuroinflammation: An Emerging Aspect of Nervous System Pathology
Joint Authors
Perrotta, Cristiana
Clementi, Emilio
Assi, Emma
Cazzato, Denise
De Palma, Clara
Cervia, Davide
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Sphingolipid metabolism is deeply regulated along the differentiation and development of the central nervous system (CNS), and the expression of a peculiar spatially and temporarily regulated sphingolipid pattern is essential for the maintenance of the functional integrity of the nervous system.
Microglia are resident macrophages of the CNS involved in general maintenance of neural environment.
Modulations in microglia phenotypes may contribute to pathogenic forms of inflammation.
Since defects in macrophage/microglia activity contribute to neurodegenerative diseases, it will be essential to systematically identify the components of the microglial cell response that contribute to disease progression.
In such complex processes, the sphingolipid systems have recently emerged to play important roles, thus appearing as a key new player in CNS disorders.
This review provides a rationale for harnessing the sphingolipid metabolic pathway as a potential target against neuroinflammation.
American Psychological Association (APA)
Assi, Emma& Cazzato, Denise& De Palma, Clara& Perrotta, Cristiana& Clementi, Emilio& Cervia, Davide. 2013. Sphingolipids and Brain Resident Macrophages in Neuroinflammation: An Emerging Aspect of Nervous System Pathology. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1006596
Modern Language Association (MLA)
Assi, Emma…[et al.]. Sphingolipids and Brain Resident Macrophages in Neuroinflammation: An Emerging Aspect of Nervous System Pathology. Journal of Immunology Research No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1006596
American Medical Association (AMA)
Assi, Emma& Cazzato, Denise& De Palma, Clara& Perrotta, Cristiana& Clementi, Emilio& Cervia, Davide. Sphingolipids and Brain Resident Macrophages in Neuroinflammation: An Emerging Aspect of Nervous System Pathology. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1006596
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006596