IL-6 is Upregulated in Late-Stage Disease in Monkeys Experimentally Infected with Trypanosoma brucei rhodesiense
Joint Authors
Ngotho, Maina
Wangari Maina, Naomi
Kagira, John Maina
Nyawira Maranga, Dawn
Muturi Karanja, Simon
Kinyanjui, Christopher Kariuki
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The management of human African trypanosomiasis (HAT) is constrained by lack of simple-to-use diagnostic, staging, and treatment tools.
The search for novel biomarkers is, therefore, essential in the fight against HAT.
The current study aimed at investigating the potential of IL-6 as an adjunct parameter for HAT stage determination in vervet monkey model.
Four adult vervet monkeys (Chlorocebus aethiops) were experimentally infected with Trypanosoma brucei rhodesiense and treated subcuratively at 28 days after infection (dpi) to induce late stage disease.
Three noninfected monkeys formed the control group.
Cerebrospinal fluid (CSF) and blood samples were obtained at weekly intervals and assessed for various biological parameters.
A typical HAT-like infection was observed.
The late stage was characterized by significant (P<0.05) elevation of CSF IL-6, white blood cell count, and total protein starting 35 dpi with peak levels of these parameters coinciding with relapse parasitaemia.
Brain immunohistochemical staining revealed an increase in brain glial fibrillary acidic protein expression indicative of reactive astrogliosis in infected animals which were euthanized in late-stage disease.
The elevation of IL-6 in CSF which accompanied other HAT biomarkers indicates onset of parasite neuroinvasion and show potential for use as an adjunct late-stage disease biomarker in the Rhodesian sleeping sickness.
American Psychological Association (APA)
Nyawira Maranga, Dawn& Kagira, John Maina& Kinyanjui, Christopher Kariuki& Muturi Karanja, Simon& Wangari Maina, Naomi& Ngotho, Maina. 2013. IL-6 is Upregulated in Late-Stage Disease in Monkeys Experimentally Infected with Trypanosoma brucei rhodesiense. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1006601
Modern Language Association (MLA)
Nyawira Maranga, Dawn…[et al.]. IL-6 is Upregulated in Late-Stage Disease in Monkeys Experimentally Infected with Trypanosoma brucei rhodesiense. Journal of Immunology Research No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1006601
American Medical Association (AMA)
Nyawira Maranga, Dawn& Kagira, John Maina& Kinyanjui, Christopher Kariuki& Muturi Karanja, Simon& Wangari Maina, Naomi& Ngotho, Maina. IL-6 is Upregulated in Late-Stage Disease in Monkeys Experimentally Infected with Trypanosoma brucei rhodesiense. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1006601
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006601