Antigen-Specific Gene Therapy after Immunisation Reduces the Severity of Collagen-Induced Arthritis
Joint Authors
Henningsson, Louise
Tengvall, Sara
Holmdahl, Rikard
Jirholt, Pernilla
Eneljung, Tove
Gustafsson, Kenth
Gjertsson, Inger
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Reestablishment of tolerance induction in rheumatoid arthritis (RA) would be an optimal treatment with few, if any, side effects.
However, to develop such a treatment further insights in the immunological mechanisms governing tolerance are needed.
We have developed a model of antigen-specific tolerance in collagen type II (CII) induced arthritis (CIA) using lentivirus-based gene therapy.
The immunodominant epitope of CII was inserted into a lentivirus vector to achieve expression on the MHC class II molecule and the lentiviral particles were subsequently intravenously injected at different time points during CIA.
Injection of lentiviral particles in early phases of CIA, that is, at day 7 or day 26 after CII immunisation, partially prevented development of arthritis, decreased the serum levels of CII-specific IgG antibodies, and enhanced the suppressive function of CII-specific T regulatory cells.
When lentiviral particles were injected during manifest arthritis, that is, at day 31 after CII immunisation, the severity of arthritis progression was ameliorated, the levels of CII-specific IgG antibodies decreased and the proportion of T regulatory cells increased.
Thus, antigen-specific gene therapy is effective when administered throughout the inflammatory course of arthritis and offers a good model for investigation of the basic mechanisms during tolerance in CIA.
American Psychological Association (APA)
Eneljung, Tove& Tengvall, Sara& Jirholt, Pernilla& Henningsson, Louise& Holmdahl, Rikard& Gustafsson, Kenth…[et al.]. 2013. Antigen-Specific Gene Therapy after Immunisation Reduces the Severity of Collagen-Induced Arthritis. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1006636
Modern Language Association (MLA)
Eneljung, Tove…[et al.]. Antigen-Specific Gene Therapy after Immunisation Reduces the Severity of Collagen-Induced Arthritis. Journal of Immunology Research No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1006636
American Medical Association (AMA)
Eneljung, Tove& Tengvall, Sara& Jirholt, Pernilla& Henningsson, Louise& Holmdahl, Rikard& Gustafsson, Kenth…[et al.]. Antigen-Specific Gene Therapy after Immunisation Reduces the Severity of Collagen-Induced Arthritis. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1006636
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006636