Recent Advances in the Pathogenesis of Autoimmune Hair Loss Disease Alopecia Areata
Author
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Alopecia areata is considered to be a cell-mediated autoimmune disease, in which autoreactive cytotoxic T cells recognize melanocyte-associated proteins such as tyrosinase.
This review discusses recent advances in the understanding of the pathogenesis of alopecia areata, focusing on immunobiology and hormonal aspects of hair follicles (HFs).
The HF is a unique “miniorgan” with its own immune and hormonal microenvironment.
The immunosuppressive milieu of the anagen hair bulb modulated by immunosuppressive factors is known as “hair follicle immune privilege.” The collapse of the hair follicle immune privilege leads to autoimmune reactions against hair follicle autoantigens.
Alopecia areata is sometimes triggered by viral infections such as influenza that causes excess production of interferons (IFN).
IFN-γ is one of the key factors that lead to the collapse of immune privilege.
This paper reviews the interactions between the endocrine and immune systems and hair follicles in the pathogenesis of alopecia areata.
American Psychological Association (APA)
Ito, Taisuke. 2013. Recent Advances in the Pathogenesis of Autoimmune Hair Loss Disease Alopecia Areata. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1006641
Modern Language Association (MLA)
Ito, Taisuke. Recent Advances in the Pathogenesis of Autoimmune Hair Loss Disease Alopecia Areata. Journal of Immunology Research No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1006641
American Medical Association (AMA)
Ito, Taisuke. Recent Advances in the Pathogenesis of Autoimmune Hair Loss Disease Alopecia Areata. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1006641
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006641