Helicobacter pylori Infection and Light Chain Gammopathy
Joint Authors
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Helicobacter pylori provokes a host of immune alterations upon colonizing the gastric mucosa.
Design.
We report 22 individuals with confirmed Helicobacter pylori infection who were also managed for the concurrent elevation of immunoglobulin free light chain (kappa and lambda) levels.
Result.
Of the 22 patients, 15 patients (68.2%) had elevated free light chain levels: 6 patients (40%) had only kappa chain elevation, 2 patients (13.3%) had only lambda chain elevation, and 7 patients (46.7%) had both kappa and lambda chain elevation.
Twenty out of the 22 patients (90.9%) were microbiologically confirmed cured with 3 patients being lost to follow-up for repeat levels.
Of the 3 patients who were lost to follow-up, 1 patient had only kappa chain elevation, 1 patient had only lambda chain elevation, and 1 patient had both kappa and lambda chain elevation.
For those who were cured (19 patients), 5 patients with kappa elevation had normalized values, 4 patients with lambda elevation had normalized values, and 2 patients with combined kappa and lambda elevation had normalized values.
For 6 out of the 19 patients, the light chain levels remained elevated.
Conclusion.
We speculate that the Helicobacter pylori infection disrupts the immunoglobulin system with potential implications being discussed below.
American Psychological Association (APA)
Girón, José A.& Shah, Shawn L.. 2013. Helicobacter pylori Infection and Light Chain Gammopathy. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1006642
Modern Language Association (MLA)
Girón, José A.& Shah, Shawn L.. Helicobacter pylori Infection and Light Chain Gammopathy. Journal of Immunology Research No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1006642
American Medical Association (AMA)
Girón, José A.& Shah, Shawn L.. Helicobacter pylori Infection and Light Chain Gammopathy. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1006642
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006642