Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation Site
Joint Authors
Pepper, Andrew R.
Shapiro, A. M. James
Ziff, Oliver J.
Gala-Lopez, Boris
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-08
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Since the initial reporting of the successful reversal of hyperglycemia through the transplantation of pancreatic islets, significant research efforts have been conducted in elucidating the process of revascularization and the influence of engraftment site on graft function and survival.
During the isolation process the intrinsic islet vascular networks are destroyed, leading to impaired revascularization after transplant.
As a result, in some cases a significant quantity of the beta cell mass transplanted dies acutely following the infusion into the portal vein, the most clinically used site of engraftment.
Subsequently, despite the majority of patients achieving insulin independence after transplant, a proportionof themrecommence small, supplemental exogenous insulin over time.
Herein, this review considers the process of islet revascularization after transplant, its limiting factors, and potential strategies to improve this critical step.
Furthermore, we provide a characterization of alternative transplant sites, analyzing the historical evolution and their role towards advancing transplant outcomes in both the experimental and clinical settings.
American Psychological Association (APA)
Pepper, Andrew R.& Gala-Lopez, Boris& Ziff, Oliver J.& Shapiro, A. M. James. 2013. Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation Site. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1006645
Modern Language Association (MLA)
Pepper, Andrew R.…[et al.]. Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation Site. Journal of Immunology Research No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-1006645
American Medical Association (AMA)
Pepper, Andrew R.& Gala-Lopez, Boris& Ziff, Oliver J.& Shapiro, A. M. James. Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation Site. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1006645
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006645