TSE Diagnostics: Recent Advances in Immunoassaying Prions
Joint Authors
Čurin Šerbec, Vladka
Lukan, Anja
Vranac, Tanja
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Transmissible spongiform encephalopathies (TSEs) or prion diseases are a group of rare fatal neurodegenerative diseases, affecting humans and animals.
They are believed to be the consequence of the conversion of the cellular prion protein to its aggregation-prone, β-sheet-rich isoform, named prion.
Definite diagnosis of TSEs is determined post mortem.
For this purpose, immunoassays for analyzing brain tissue have been developed.
However, the ultimate goal of TSE diagnostics is an ante mortem test, which would be sensitive enough to detect prions in body fluids, that is, in blood, cerebrospinal fluid, or urine.
Such a test would be of paramount importance also for screening of asymptomatic carriers of the disease with the aim of increasing food, drugs, and blood-derived products safety.
In the present paper, we have reviewed recent advances in the development of immunoassays for the detection of prions.
American Psychological Association (APA)
Lukan, Anja& Vranac, Tanja& Čurin Šerbec, Vladka. 2013. TSE Diagnostics: Recent Advances in Immunoassaying Prions. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1006647
Modern Language Association (MLA)
Lukan, Anja…[et al.]. TSE Diagnostics: Recent Advances in Immunoassaying Prions. Journal of Immunology Research No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1006647
American Medical Association (AMA)
Lukan, Anja& Vranac, Tanja& Čurin Šerbec, Vladka. TSE Diagnostics: Recent Advances in Immunoassaying Prions. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1006647
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006647