Systemic and Nonrenal Adverse Effects Occurring in Renal Transplant Patients Treated with mTOR Inhibitors
Joint Authors
Granata, Simona
Ria, Paolo
Tomei, Paola
Zaza, Gianluigi
Boschiero, Luigino
Lupo, Antonio
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-19
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The mammalian target of rapamycin inhibitors (mTOR-I), sirolimus and everolimus, are immunosuppressive drugs largely used in renal transplantation.
The main mechanism of action of these drugs is the inhibition of the mammalian target of rapamycin (mTOR), a regulatory protein kinase involved in lymphocyte proliferation.
Additionally, the inhibition of the crosstalk among mTORC1, mTORC2, and PI3K confers the antineoplastic activities of these drugs.
Because of their specific pharmacological characteristics and their relative lack of nephrotoxicity, these inhibitors are valid option to calcineurine inhibitors (CNIs) for maintenance immunosuppression in renal transplant recipients with chronic allograft nephropathy.
However, as other immunosuppressive drugs, mTOR-I may induce the development of several adverse effects that need to be early recognized and treated to avoid severe illness in renal transplant patients.
In particular, mTOR-I may induce systemic nonnephrological side effects including pulmonary toxicity, hematological disorders, dysmetabolism, lymphedema, stomatitis, cutaneous adverse effects, and fertility/gonadic toxicity.
Although most of the adverse effects are dose related, it is extremely important for clinicians to early recognize them in order to reduce dosage or discontinue mTOR-I treatment avoiding the onset and development of severe clinical complications.
American Psychological Association (APA)
Zaza, Gianluigi& Tomei, Paola& Ria, Paolo& Granata, Simona& Boschiero, Luigino& Lupo, Antonio. 2013. Systemic and Nonrenal Adverse Effects Occurring in Renal Transplant Patients Treated with mTOR Inhibitors. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1006676
Modern Language Association (MLA)
Zaza, Gianluigi…[et al.]. Systemic and Nonrenal Adverse Effects Occurring in Renal Transplant Patients Treated with mTOR Inhibitors. Journal of Immunology Research No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-1006676
American Medical Association (AMA)
Zaza, Gianluigi& Tomei, Paola& Ria, Paolo& Granata, Simona& Boschiero, Luigino& Lupo, Antonio. Systemic and Nonrenal Adverse Effects Occurring in Renal Transplant Patients Treated with mTOR Inhibitors. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1006676
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006676