Asymptomatic Preclinical Rheumatoid Arthritis-Associated Interstitial Lung Disease
Joint Authors
Wang, XiaoPing
Ascheman, Dana P.
Shi, YongHong
Chen, Juan
Huang, Heqing
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Interstitial lung disease (ILD) is a common extra-articular manifestation of rheumatoid arthritis (RA) and a significant cause of morbidity and mortality.
The objective of this study was to define high-resolution chest CT (HRCT) and pulmonary function test (PFT) abnormalities capable of identifying asymptomatic, preclinical forms of RA-ILD that may represent precursors to more severe fibrotic lung disease.
Methods.
We analyzed chest HRCTs in consecutively enrolled RA patients and subsequently classified these individuals as RA-ILD or RA-no ILD based on the presence/absence of ground glass opacification, septal thickening, reticulation, traction bronchiectasis, and/or honeycombing.
Coexisting PFT abnormalities (reductions in percent predicted FEV1, FVC, TLC, and/or DLCO) were also used to further characterize occult respiratory defects.
Results.
61% (63/103) of RA patients were classified as RA-ILD based on HRCT and PFT abnormalities, while 39% (40/103) were designated as RA-no ILD.
57/63 RA-ILD patients lacked symptoms of significant dyspnea or cough at the time of HRCT and PFT assessment.
Compared with RA-no ILD, RA-ILD patients were older and had longer disease duration, higher articular disease activity, and more significant PFT abnormalities.
Conclusion.
HRCT represents an effective tool to detect occult/asymptomatic ILD that is highly prevalent in our unselected, university-based cohort of RA patients.
American Psychological Association (APA)
Chen, Juan& Shi, YongHong& Wang, XiaoPing& Huang, Heqing& Ascheman, Dana P.. 2013. Asymptomatic Preclinical Rheumatoid Arthritis-Associated Interstitial Lung Disease. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1006678
Modern Language Association (MLA)
Chen, Juan…[et al.]. Asymptomatic Preclinical Rheumatoid Arthritis-Associated Interstitial Lung Disease. Journal of Immunology Research No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1006678
American Medical Association (AMA)
Chen, Juan& Shi, YongHong& Wang, XiaoPing& Huang, Heqing& Ascheman, Dana P.. Asymptomatic Preclinical Rheumatoid Arthritis-Associated Interstitial Lung Disease. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1006678
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006678