Long-Term Safety of Anti-TNF Adalimumab in HBc Antibody-Positive Psoriatic Arthritis Patients: A Retrospective Case Series of 8 Patients
Joint Authors
Viviano, M. T.
Leoni, L.
Migliore, A.
Ballanti, E.
Laurenti, R.
Giovannangeli, F.
Errico, A.
Gubinelli, E.
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-27
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Immunosuppressive drugs commonly used in the treatment of psoriatic arthritis make patients more susceptible to viral, bacterial, and fungal infections because of their mechanism of action.
They not only increase the risk of new infections but also act altering the natural course of preexisting infections.
While numerous data regarding the reactivation of tuberculosis infection are available in the literature, poor information about the risk of reactivation or exacerbation of hepatitis viruses B and C infections during treatment with biologics has been reported.
Furthermore, reported series with biological therapy included short periods of followup, and therefore, they are not adequate to verify the risk of reactivation in the long-term treatment.
Our study evaluated patients with a history of hepatitis B and psoriatic arthritis treated with adalimumab and monitored up to six years.
During the observation period, treatment was effective and well tolerated in all patients, and liver function tests and viral load levels remained unchanged.
American Psychological Association (APA)
Laurenti, R.& Giovannangeli, F.& Gubinelli, E.& Viviano, M. T.& Errico, A.& Leoni, L.…[et al.]. 2013. Long-Term Safety of Anti-TNF Adalimumab in HBc Antibody-Positive Psoriatic Arthritis Patients: A Retrospective Case Series of 8 Patients. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1006679
Modern Language Association (MLA)
Laurenti, R.…[et al.]. Long-Term Safety of Anti-TNF Adalimumab in HBc Antibody-Positive Psoriatic Arthritis Patients: A Retrospective Case Series of 8 Patients. Journal of Immunology Research No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1006679
American Medical Association (AMA)
Laurenti, R.& Giovannangeli, F.& Gubinelli, E.& Viviano, M. T.& Errico, A.& Leoni, L.…[et al.]. Long-Term Safety of Anti-TNF Adalimumab in HBc Antibody-Positive Psoriatic Arthritis Patients: A Retrospective Case Series of 8 Patients. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1006679
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006679