Immunogenetic Study in Chinese Population with Ankylosing Spondylitis: Are There Specific Genes Recently Disclosed?
Joint Authors
Rong, Ju
Zhai, Jiayu
Li, Qiuxia
Gu, Jieruo
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
Ankylosing spondylitis (AS) is a systemic, autoimmune disease resulting in the destruction of the affected joints.
Over the past 5 years, several new genes or genetic regions associated with AS have been identified in the Chinese population.
This paper aims to discuss the major findings and related potential mechanisms of these studies in our population.
Recent Findings.
In recent years, due to the rapid advances in computational genetics and technology, there has been an increasing list of well-validated genes or genetic regions associated with AS susceptibility.
So far, several genes or genetic regions have now been reported in the Han ethnic Chinese population, containing the major histocompatibility complex (MHC), ERAP1, IL-23R, 12q12, 2p15, 5q14.3, and so on.
Different hypotheses for disease mechanisms have been investigated on the basis of the functional studies of these genes or genetic regions.
Summary.
This paper tries to summarize the association of several candidate genes with risk for AS in the Han ethnic Chinese population and aims to identify the novel inflammatory pathways and provide potential strategies for better therapies.
American Psychological Association (APA)
Zhai, Jiayu& Rong, Ju& Li, Qiuxia& Gu, Jieruo. 2013. Immunogenetic Study in Chinese Population with Ankylosing Spondylitis: Are There Specific Genes Recently Disclosed?. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1006708
Modern Language Association (MLA)
Zhai, Jiayu…[et al.]. Immunogenetic Study in Chinese Population with Ankylosing Spondylitis: Are There Specific Genes Recently Disclosed?. Journal of Immunology Research No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1006708
American Medical Association (AMA)
Zhai, Jiayu& Rong, Ju& Li, Qiuxia& Gu, Jieruo. Immunogenetic Study in Chinese Population with Ankylosing Spondylitis: Are There Specific Genes Recently Disclosed?. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1006708
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006708